Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK.
Adv Drug Deliv Rev. 2011 Sep 16;63(12):1031-41. doi: 10.1016/j.addr.2011.05.012. Epub 2011 Jun 12.
Carbon nanotube interaction with an important part of the innate immune system, complement, needs to be taken into account when envisaging their use in biomedical applications. Carbon nanotubes (CNTs) and other synthetic materials are recognized by various components of the complement system in human or mammalian blood and also collectins in the lungs. Modification of the surface chemistry of CNTs alters their interactions with complement proteins and collectins. Functionalizations of CNTs which have been tested so far do not completely prevent complement activation or plasma protein binding. The interaction of the functionalized CNTs with the complement system proteins in blood may influence the adhesion of CNTs to phagocytic cells and red blood cells. Excessive activation of complement can have a harmful effect on human tissues and therefore significantly limit CNT applications in biomedicine.
在设想将碳纳米管用于生物医学应用时，需要考虑它们与先天免疫系统中重要部分——补体的相互作用。碳纳米管（CNTs）和其他合成材料会被人类或哺乳动物血液中的补体系统的各种成分以及肺部的 collectins 识别，并且 CNT 还会收集 collectins。CNTs 表面化学性质的改变会改变它们与补体蛋白和 collectins 的相互作用。到目前为止，经过测试的 CNT 功能化并不能完全阻止补体激活或血浆蛋白结合。功能化的 CNT 与血液中补体系统蛋白的相互作用可能会影响 CNT 与吞噬细胞和红细胞的黏附。补体的过度激活可能对人体组织产生有害影响，因此会极大地限制 CNT 在生物医学中的应用。
