Centre for Pharmaceutical Nanotechnology and Nanotoxicology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark.
Adv Drug Deliv Rev. 2011 Sep 16;63(12):1000-7. doi: 10.1016/j.addr.2011.06.002. Epub 2011 Jun 12.
Uncontrolled complement activation can induce many inflammatory and life threatening conditions. Accordingly, the role of complement in initiation of adverse reactions to polymers and nanoparticulate drug carriers is receiving increasing attention and has prompted extensive 'structure-immune performance' relationship studies in nanomedicine research at many fronts. The interaction between nanomaterials and the complement system is complex and regulated by inter-related factors that include nanoscale size, morphology and surface characteristics. Each of these parameters may affect complement activation differently and through different sensing molecules and initiation pathways. The importance of material properties in triggering complement is considered and mechanistic aspects discussed. Mechanistic understanding of complement events could provide rational approaches for improved material design and nanoengineering strategies for clinical medicine.
失控的补体激活可引发多种炎症和危及生命的情况。因此，补体在引发对聚合物和纳米颗粒药物载体的不良反应中的作用正受到越来越多的关注，并促使纳米医学研究在许多方面都广泛开展了“结构-免疫性能”关系研究。纳米材料与补体系统之间的相互作用非常复杂，受到相互关联的因素的调控，其中包括纳米级尺寸、形态和表面特征。这些参数中的每一个都可能通过不同的传感分子和起始途径以不同的方式影响补体激活。材料性质在触发补体中的重要性被认为，并讨论了其机制方面。对补体事件的机制理解可为改进材料设计和用于临床医学的纳米工程策略提供合理的方法。
