Centre de Biologie du Développement, UMR 5547 CNRS/Université Toulouse III, 118 route de Narbonne 31062 Toulouse cedex 9, France.
Dis Model Mech. 2011 Jul;4(4):439-45. doi: 10.1242/dmm.007351. Epub 2011 Jun 13.
Vertebrate haematopoietic stem cells (HSCs) give rise to a hierarchically organised set of progenitors for erythroid, myeloid, lymphoid and megakaryocyte lineages, and are responsible for lifelong maintenance of the blood system. Dysregulation of the haematopoietic differentiation programme is at the origin of numerous pathologies, including leukaemias. With the discoveries that many transcriptional regulators and signalling pathways controlling blood cell development are conserved between humans and Drosophila melanogaster, the fruit fly has become a good model for investigating the mechanisms underlying the generation of blood cell lineages and blood cell homeostasis. In this review article, we discuss how genetic and molecular studies of Drosophila haematopoiesis can contribute to our understanding of the haematopoietic niche, as well as of the origin and/or progression of haematopoietic malignancies in humans.
脊椎动物造血干细胞 (HSCs) 产生了一系列层次化的祖细胞，用于红系、髓系、淋巴系和巨核细胞谱系，并负责终生维持血液系统。造血分化程序的失调是许多病理学的根源，包括白血病。随着人们发现控制血细胞发育的许多转录调节因子和信号通路在人类和黑腹果蝇之间是保守的，果蝇已成为研究血细胞谱系生成和血细胞内稳态的机制的良好模型。在这篇综述文章中，我们讨论了果蝇造血的遗传和分子研究如何有助于我们理解造血龛，以及人类造血恶性肿瘤的起源和/或进展。
