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肉桂啶（一种糖肉桂酰亚精胺类抗生素）对细菌DNA促旋酶的体外抑制作用。

In vitro inhibition of bacterial DNA gyrase by cinodine, a glycocinnamoylspermidine antibiotic.

作者信息

Osburne M S, Maiese W M, Greenstein M

机构信息

Lederle Laboratories, Medical Research Division, American Cyanamid Company, Pearl River, New York 10965.

出版信息

Antimicrob Agents Chemother. 1990 Jul;34(7):1450-2. doi: 10.1128/AAC.34.7.1450.

DOI:10.1128/AAC.34.7.1450
PMID:2167040
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC176000/
Abstract

Cinodine, a broad-spectrum glycocinnamoylspermidine antibiotic, binds to DNA and irreversibly inhibits bacterial and phase DNA synthesis. Cinodine was found to inhibit the activity of Micrococcus luteus DNA gyrase in vitro, but it did not inhibit the activities of two other DNA-binding enzymes, namely, topoisomerase I and BamHI. Although we cannot yet conclude that DNA gyrase is an intracellular target of the drug, in vitro inhibition of the enzyme by cinodine appears to be specific.

摘要

辛诺定是一种广谱糖肉桂酰亚精胺类抗生素，它与DNA结合并不可逆地抑制细菌及噬菌体DNA的合成。已发现辛诺定在体外可抑制藤黄微球菌DNA促旋酶的活性，但不抑制另外两种DNA结合酶，即拓扑异构酶I和BamHI的活性。虽然我们尚不能得出DNA促旋酶是该药物的细胞内靶点这一结论，但辛诺定在体外对该酶的抑制作用似乎具有特异性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b701/176000/c9975fe9b0c3/aac00063-0181-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b701/176000/23124c6333e5/aac00063-0181-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b701/176000/229dce67e605/aac00063-0181-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b701/176000/c9975fe9b0c3/aac00063-0181-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b701/176000/23124c6333e5/aac00063-0181-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b701/176000/229dce67e605/aac00063-0181-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b701/176000/c9975fe9b0c3/aac00063-0181-c.jpg

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Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase.新生霉素和香豆霉素抑制由DNA促旋酶催化的DNA超螺旋化。
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