Fu K P, Grace M E, McCloud S J, Gregory F J, Hung P P
Chemotherapy. 1986;32(6):494-8. doi: 10.1159/000238458.
Thirteen quinolone antibacterial agents were investigated as to their ability to inhibit Micrococcus luteus DNA gyrase and cell growth, and compared to those of novobiocin and coumermycin. Among the quinolones tested, the most active were found to be CI-934 and ciprofloxacin, which inhibited gyrase full supercoiling activity at concentrations of 100 and 200 micrograms/ml, respectively, while inhibiting cell growth at a concentration of 1 microgram/ml. However, both novobiocin and coumermycin inhibited gyrase full supercoiling activity at concentrations of 0.5 and 1.0 microgram/ml, respectively, which were comparable to those concentrations causing inhibition of cell growth.
研究了13种喹诺酮类抗菌剂抑制藤黄微球菌DNA促旋酶和细胞生长的能力，并与新生霉素和香豆霉素进行了比较。在所测试的喹诺酮类药物中，发现活性最高的是CI-934和环丙沙星，它们分别在100和200微克/毫升的浓度下抑制促旋酶的完全超螺旋活性，同时在1微克/毫升的浓度下抑制细胞生长。然而，新生霉素和香豆霉素分别在0.5和1.0微克/毫升的浓度下抑制促旋酶的完全超螺旋活性，这些浓度与导致细胞生长抑制的浓度相当。
