韩国 2 型糖尿病患者对甲型 H1N1 流感 2009 单价灭活疫苗的体液免疫应答。
The humoral immune response to the inactivated influenza A (H1N1) 2009 monovalent vaccine in patients with Type 2 diabetes mellitus in Korea.
机构信息
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
出版信息
Diabet Med. 2011 Jul;28(7):815-7. doi: 10.1111/j.1464-5491.2011.03255.x.
AIMS
We evaluated the antibody response to a single-dose adjuvanted, inactivated, pandemic H1N1 influenza vaccination in patients with diabetes and assessed factors associated with the failure to induce antibody responses.
METHODS
Eighty-two patients with Type 2 diabetes were vaccinated and antibody responses were determined with haemagglutination inhibition assay and anti-haemagglutinin antibody ELISA.
RESULTS
Among 70 antibody-negative patients at baseline, 34 (48.6%) achieved seroconversion; 28 (60.9%) in the young adults group and six (25%) in the elderly group acquired H1N1-specific antibodies. Patients in the older age range or with longer duration of diabetes had a lower seroconversion rate.
CONCLUSIONS
Our data show low cross-reactive antibody carrying rate and low seroconversion rate in patients with diabetes. Until larger-scale, case-controlled trials become available, older patients and patients with a longer duration of diabetes should be considered for the two-dose vaccination or have antibody titres measured after the first vaccination.
目的
我们评估了对糖尿病患者进行一剂佐剂灭活的大流行性 H1N1 流感疫苗接种后的抗体反应，并评估了与未能诱导抗体反应相关的因素。
方法
82 例 2 型糖尿病患者接种疫苗，并通过血凝抑制试验和抗血凝素抗体 ELISA 测定抗体反应。
结果
在基线时的 70 例抗体阴性患者中，34 例（48.6%）发生血清转化；年轻成人组 28 例（60.9%）和老年组 6 例（25%）获得了 H1N1 特异性抗体。年龄较大或糖尿病病程较长的患者血清转化率较低。
结论
我们的数据显示，糖尿病患者的交叉反应性抗体携带率和血清转化率较低。在更大规模的病例对照试验可用之前，应考虑对老年患者和糖尿病病程较长的患者进行两剂疫苗接种，或在第一剂疫苗接种后测量抗体滴度。
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