Laboratório de Micologia, Departamento de Microbiologia, Instituto de Ciências Biológicas (ICB), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
Mycoses. 2011 Sep;54(5):e265-71. doi: 10.1111/j.1439-0507.2010.01966.x. Epub 2011 Jun 14.
Photodynamic therapy (PDT) is a minimally invasive approach, in which a photosensitiser compound is activated by exposure to visible light. The activation of the sensitiser drug results in several chemical reactions, such as the production of oxygen reactive species and other reactive molecules, whose presence in the biological site leads to the damage of target cells. Although PDT has been primarily developed to combat cancerous lesions, this therapy can be employed for the treatment of several conditions, including infectious diseases. A wide range of microorganisms, including Gram positive and Gram negative bacteria, viruses, protozoa and fungi have demonstrated susceptibility to antimicrobial photodynamic therapy. This treatment might consist of an alternative to the management of fungal infections. Antifungal photodynamic therapy has been successfully employed against Candida albicans and other Candida species and also against dermatophytes. The strain-dependent antifungal effect and the influence of the biological medium are important issues to be considered. Besides, the choice of photosensitiser to be employed in PDT should consider the characteristics of the fungi and the medium to be treated, as well as the depth of penetration of light into the skin. In the present review, the state-of-the-art of antifungal PDT is discussed and the photosensitiser characteristics are analysed.
光动力疗法（PDT）是一种微创方法，其中光敏剂化合物通过暴露于可见光而被激活。敏化剂药物的激活导致几种化学反应，例如产生氧反应性物质和其他反应性分子，其在生物部位的存在导致靶细胞的损伤。尽管 PDT 主要是为了对抗癌性病变而开发的，但这种疗法可用于治疗多种疾病，包括传染病。包括革兰氏阳性和革兰氏阴性细菌、病毒、原生动物和真菌在内的多种微生物对抗菌光动力疗法表现出敏感性。这种治疗方法可能是治疗真菌感染的一种替代方法。抗真菌光动力疗法已成功用于治疗白色念珠菌和其他念珠菌以及皮肤真菌。菌株依赖性抗真菌作用和生物介质的影响是需要考虑的重要问题。此外，用于 PDT 的光敏剂的选择应考虑真菌和待处理介质的特性，以及光进入皮肤的深度。在本综述中，讨论了抗真菌 PDT 的最新技术，并分析了光敏剂的特性。
