Allergy/Immunology Division, Albert Einstein College of Medicine, Bronx, NY 10463, USA.
Clin Exp Allergy. 2011 Nov;41(11):1515-20. doi: 10.1111/j.1365-2222.2011.03797.x. Epub 2011 Jun 14.
Atopic dermatitis (AD), a skin disease characterized by pruritus and chronic inflammation, results from a complex interplay between environmental and genetic factors. Thymic stromal lymphopoietin (TSLP), an IL-7-like cytokine, is believed to propagate AD lesions through T helper 2 (Th2) polarization. This paper describes the immunologic mechanisms involving TSLP in the generation of allergic disease. Specifically in AD, TSLP has been shown to be an inducer of myeloid dendritic cells, Th2 responses, mast cells, and natural killer T cells, thereby leading to cytokine secretion and the development of AD. We hope that further understanding of the TSLP pathway and its role in the pathogenesis of AD will lead to improved clinical management of AD in the future.
特应性皮炎（AD）是一种以瘙痒和慢性炎症为特征的皮肤病，是环境和遗传因素复杂相互作用的结果。胸腺基质淋巴细胞生成素（TSLP）是一种类似于白细胞介素-7 的细胞因子，被认为通过辅助性 T 细胞 2（Th2）极化来促进 AD 病变。本文描述了 TSLP 在过敏性疾病发生中的免疫机制。具体在 AD 中，TSLP 已被证明可诱导髓样树突状细胞、Th2 反应、肥大细胞和自然杀伤 T 细胞，从而导致细胞因子分泌和 AD 的发展。我们希望对 TSLP 途径及其在 AD 发病机制中的作用的进一步了解将导致未来 AD 的临床管理得到改善。
