John Walls Renal Unit, Leicester General Hospital, Leicester, UK.
Kidney Int. 2011 Jul;80(1):8-10. doi: 10.1038/ki.2011.83.
New data from Kiryluk et al. show the importance of genetic factors in determining the profile of serum IgA1 O-glycoforms in IgA nephropathy and Henoch-Schönlein purpura nephritis. Elevated serum levels of poorly galactosylated IgA1 O-glycoforms do not, however, appear sufficient in themselves to cause nephritis in these two diseases, and a 'second hit' is necessary before changes in IgA1 glycosylation translate into clinical disease. The challenge now is to determine what these genetic factors are.
基里卢克等人的新数据表明，遗传因素在决定 IgA 肾病和过敏性紫癜性肾炎患者血清 IgA1 O-聚糖结构的特征方面具有重要作用。然而，血清中未经充分半乳糖基化的 IgA1 O-聚糖结构水平升高本身似乎并不足以导致这两种疾病发生肾炎，只有在 IgA1 糖基化发生变化导致临床疾病之前存在“二次打击”，才会导致疾病发生。目前的挑战是确定这些遗传因素是什么。
