Moore D E, Segars J H, Winfield A C, Page D L, Eisenberg A D, Holburn G E
Department of Radiology and Radiological Sciences, Vanderbilt University School of Medicine, Nashville, TN 37232.
Radiology. 1990 Sep;176(3):721-4. doi: 10.1148/radiology.176.3.2167499.
The authors evaluated the effect of different iodinated contrast agents on the fallopian tube and adnexal tissue in 15 rabbits. Ethiodized oil, an oil-soluble agent, was used in five rabbits. The following water-soluble agents were used: iothalamate meglumine 30% (n = 3), iothalamate meglumine 60% (n = 3), and ioxilan (n = 4). The agents were injected through catheters placed in the fallopian tubes. Fallopian tubes and peritoneal cavities were histologically evaluated. The contralateral tube served as a control. Ioxilan and iothalamate meglumine 30% produced no pathologic response in the tube or peritoneal cavity. Iothalamate meglumine 60% was associated with mild inflammatory infiltrate, mucosal edema, giant cell reaction, and periovarian adhesions that were bilateral but more pronounced on the injected side. Use of ethiodized oil resulted in papillary fibrous adhesions on the ovarian surface, and fat granulomas were seen in the periovarian tissues. The safety of oil-based contrast agents for use in hysterosalpingography is therefore questioned. No significant differences were found among the water-soluble contrast agents.
作者评估了不同碘化造影剂对15只兔子输卵管及附件组织的影响。5只兔子使用了油溶性造影剂乙碘油。使用的水溶性造影剂如下：30%的葡甲胺碘酞（n = 3）、60%的葡甲胺碘酞（n = 3）和碘克沙醇（n = 4）。造影剂通过置于输卵管的导管注入。对输卵管和腹腔进行了组织学评估。对侧输卵管作为对照。碘克沙醇和30%的葡甲胺碘酞在输卵管或腹腔未产生病理反应。60%的葡甲胺碘酞与轻度炎症浸润、黏膜水肿、巨细胞反应及卵巢周围粘连有关，粘连为双侧性，但注射侧更明显。使用乙碘油导致卵巢表面出现乳头状纤维粘连，卵巢周围组织可见脂肪肉芽肿。因此，油基造影剂用于子宫输卵管造影的安全性受到质疑。水溶性造影剂之间未发现显著差异。
