Eisenberg A D, Winfield A C, Page D L, Holburn G E, Schifter T, Segars J H
Department of Radiology and Radiological Sciences, Vanderbilt University School of Medicine, Nashville, TN 37232.
Radiology. 1989 Jul;172(1):149-51. doi: 10.1148/radiology.172.1.2544920.
A consensus does not exist as to the optimal contrast agent for hysterosalpingography. This study was undertaken to evaluate the early and delayed inflammatory responses of the peritoneal surfaces to various types of iodinated contrast media. Guinea pigs received intraperitoneal injections of lactated Ringer solution, iothalamate meglumine, diatrizoate sodium, ioxilan, or ethiodized oil. The inflammatory response of the peritoneal surfaces was assessed at 1,7, and 30 days. Five animals were studied at each time point for each agent. No animals that received Ringer lactate or iothalamate meglumine had inflammation at any time. Ioxilan produced inflammation in two of five animals at 7 days and no inflammation at 1 or 30 days. Ethiodized oil produced no inflammation at 1 day; however, three animals had inflammation at 7 days, and all five had inflammation at 30 days. The 30-day group showed striking inflammatory response with granulomatous features. The authors recommend the continued use of meglumine-based water-soluble ionic contrast material for hysterosalpingography.
关于子宫输卵管造影的最佳造影剂尚无共识。本研究旨在评估腹膜表面对各种碘化造影剂的早期和延迟炎症反应。豚鼠接受腹腔注射乳酸林格氏液、碘他拉葡胺、泛影酸钠、碘克沙醇或乙碘油。在第1、7和30天评估腹膜表面的炎症反应。每种造影剂在每个时间点研究5只动物。接受乳酸林格氏液或碘他拉葡胺的动物在任何时候都没有炎症。碘克沙醇在7天时使5只动物中的2只出现炎症，在1天或30天时没有炎症。乙碘油在1天时没有引起炎症；然而，3只动物在7天时出现炎症，所有5只在30天时都有炎症。30天组显示出具有肉芽肿特征的显著炎症反应。作者建议在子宫输卵管造影中继续使用基于葡甲胺的水溶性离子造影剂。
