Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box 193-4763, Tehran, Iran.
Atherosclerosis. 2011 Sep;218(1):238-42. doi: 10.1016/j.atherosclerosis.2011.05.016. Epub 2011 May 23.
Vitamin D status seems to have an association with cardiometabolic risk factors and its deficiency may negatively affect the cardiovascular outcomes. The aim of this study was to determine the possible association between vitamin D status and cardiovascular outcomes.
We performed a nested case control study within the Tehran Lipid and Glucose Study (TLGS), which followed a representative sample of Tehranian adults. A total of 251 matched pairs, aged>30 years, were selected. Cases were TLGS individuals that were free of cardiovascular disease (CVD) at the beginning of study and developed CVD during assessments of 5.7 year follow up. Each case was matched by age, sex and the month of entry to study with a randomly selected control (risk-set sampling). Prespecified cut points were used to characterize varying degrees of 25-OH D deficiency (<10, between 10 and 14.9, and ≥ 15 ng/ml). Conditional logistic regression was used to investigate the association between 25-OH-D concentration and the incident cardiovascular outcomes.
The mean age of participants was 56.84 ± 11.17 years and 244 (48.6%) were women. The median (IQ: 25-75) of serum 25-OH-D was 14.1 ng/ml (9.6-29 ng/ml) and 306 (61%) of participants had serum 25-OH-D<15 g/ml. Median serum 25-OH-D was lower in cases (12.5 vs. 18.1, P<0.001). After adjustment for potential confounders, the odds ratio of serum 25-OH-D<10 ng/ml for having CVD outcomes was 2.90 compared with 25-OH-D ≥ 15 (95% confidence interval (CI): 1.67-5.12, P<0.001).
Our results indicate that serum 25-OH-D concentration has an independent association with cardiovascular outcomes in adult Tehranians.
维生素 D 状况似乎与心血管代谢危险因素有关，其缺乏可能对心血管结局产生负面影响。本研究旨在确定维生素 D 状况与心血管结局之间的可能关联。
我们在德黑兰血脂和血糖研究（TLGS）中进行了一项巢式病例对照研究，该研究随访了德黑兰成年人的代表性样本。共选择了 251 对年龄>30 岁的匹配对子。病例是 TLGS 个体，在研究开始时没有心血管疾病（CVD），并在 5.7 年的随访评估中发生了 CVD。每个病例均按年龄、性别和进入研究的月份与随机选择的对照（风险集抽样）相匹配。使用预设切点来描述 25-OHD 缺乏的不同程度（<10、10-14.9 和≥15ng/ml）。条件逻辑回归用于研究 25-OH-D 浓度与新发心血管结局之间的关系。
参与者的平均年龄为 56.84±11.17 岁，244 人（48.6%）为女性。血清 25-OH-D 的中位数（IQ：25-75）为 14.1ng/ml（9.6-29ng/ml），306 人（61%）的血清 25-OH-D<15g/ml。病例组的血清 25-OH-D 中位数较低（12.5 与 18.1，P<0.001）。在调整潜在混杂因素后，血清 25-OH-D<10ng/ml 发生 CVD 结局的比值比为 2.90，与 25-OH-D≥15ng/ml 相比（95%置信区间（CI）：1.67-5.12，P<0.001）。
我们的结果表明，血清 25-OH-D 浓度与成年德黑兰人的心血管结局独立相关。
