Department of Neurology, University of Pennsylvania, United States; Penn Epilepsy Center, United States.
Epilepsy Res. 2011 Sep;96(1-2):116-22. doi: 10.1016/j.eplepsyres.2011.05.011. Epub 2011 Jun 14.
We present results from continuous intracranial electroencephalographic (iEEG) monitoring in 6 dogs with naturally occurring epilepsy, a disorder similar to the human condition in its clinical presentation, epidemiology, electrophysiology and response to therapy. Recordings were obtained using a novel implantable device wirelessly linked to an external, portable real-time processing unit. We demonstrate previously uncharacterized intracranial seizure onset patterns in these animals that are strikingly similar in appearance to human partial onset epilepsy. We propose: (1) canine epilepsy as an appropriate model for testing human antiepileptic devices and new approaches to epilepsy surgery, and (2) this new technology as a versatile platform for evaluating seizures and response to therapy in the natural, ambulatory setting.
我们展示了 6 只患有自然发生癫痫的狗的连续颅内脑电图 (iEEG) 监测结果，这种疾病在临床表现、流行病学、电生理学和治疗反应方面与人类状况相似。记录是使用一种新型可植入设备无线连接到外部便携式实时处理单元获得的。我们展示了这些动物以前未被描述的颅内癫痫发作模式，其外观与人类部分发作性癫痫非常相似。我们提出：(1) 犬癫痫作为测试人类抗癫痫设备和癫痫手术新方法的合适模型，以及 (2) 这项新技术作为评估自然环境中发作和治疗反应的多功能平台。
