• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

新型肌醇脂质磷脂酰肌醇3,4 - 二磷酸在凝血酶刺激下由人血小板产生。

The novel inositol lipid phosphatidylinositol 3,4-bisphosphate is produced by human blood platelets upon thrombin stimulation.

作者信息

Sultan C, Breton M, Mauco G, Grondin P, Plantavid M, Chap H

机构信息

INSERM Unité 326, Hôpital Purpan, Toulouse, France.

出版信息

Biochem J. 1990 Aug 1;269(3):831-4. doi: 10.1042/bj2690831.

DOI:10.1042/bj2690831
PMID:2167665
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1131663/
Abstract

Radioactive PtdIns(3)P was detected in human platelets incubated with [32P]Pi, but remained unaffected by thrombin treatment. In contrast, [32P]PtdIns(3,4)P2 was absent from resting platelets, but was produced by thrombin-activated platelets in a dose- and time-dependent manner. [32P]PtdInsP3 was never found under these conditions. These changes are similar to those elicited in other cells by platelet-derived growth factor or the oncogene product pp60c-src.

摘要

在用[32P]Pi孵育的人血小板中检测到放射性磷脂酰肌醇-3-磷酸（PtdIns(3)P），但其不受凝血酶处理的影响。相比之下，静息血小板中不存在[32P]磷脂酰肌醇-3,4-二磷酸（PtdIns(3,4)P2），但凝血酶激活的血小板以剂量和时间依赖性方式产生[32P]PtdIns(3,4)P2。在这些条件下从未发现[32P]磷脂酰肌醇-3,4,5-三磷酸（PtdInsP3）。这些变化类似于血小板衍生生长因子或癌基因产物pp60c-src在其他细胞中引起的变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7030/1131663/c6db8542124e/biochemj00178-0259-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7030/1131663/c6db8542124e/biochemj00178-0259-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7030/1131663/c6db8542124e/biochemj00178-0259-a.jpg

相似文献

1
The novel inositol lipid phosphatidylinositol 3,4-bisphosphate is produced by human blood platelets upon thrombin stimulation.新型肌醇脂质磷脂酰肌醇3,4 - 二磷酸在凝血酶刺激下由人血小板产生。
Biochem J. 1990 Aug 1;269(3):831-4. doi: 10.1042/bj2690831.
2
Synthesis of phosphatidylinositol 3,4-bisphosphate but not phosphatidylinositol 3,4,5-trisphosphate is closely correlated with protein-tyrosine phosphorylation in thrombin-activated human platelets.在凝血酶激活的人血小板中，磷脂酰肌醇3,4-二磷酸而非磷脂酰肌醇3,4,5-三磷酸的合成与蛋白酪氨酸磷酸化密切相关。
Biochem Biophys Res Commun. 1992 Aug 14;186(3):1480-6. doi: 10.1016/s0006-291x(05)81573-6.
3
Human platelets form 3-phosphorylated phosphoinositides in response to alpha-thrombin, U46619, or GTP gamma S.人类血小板在受到α-凝血酶、U46619或GTPγS刺激时会形成3-磷酸化磷脂酰肌醇。
J Biol Chem. 1990 Apr 5;265(10):5345-8.
4
The production of phosphatidylinositol trisphosphate is stimulated by thrombin in human platelets.凝血酶可刺激人血小板中三磷酸磷脂酰肌醇的产生。
Biochem Biophys Res Commun. 1991 Jan 31;174(2):524-8. doi: 10.1016/0006-291x(91)91448-l.
5
Elevation of cyclic AMP decreases phosphoinositide turnover and inhibits thrombin-induced secretion in human platelets.环磷酸腺苷（cAMP）水平的升高会降低磷酸肌醇的周转率，并抑制凝血酶诱导的人血小板分泌。
Biochim Biophys Acta. 1998 Nov 2;1394(2-3):235-48. doi: 10.1016/s0005-2760(98)00106-4.
6
Turnover of the phosphomonoester groups of polyphosphoinositol lipids in unstimulated human platelets.未受刺激的人血小板中多磷酸肌醇脂质磷酸单酯基团的周转
Eur J Biochem. 1987 Jul 1;166(1):3-9. doi: 10.1111/j.1432-1033.1987.tb13475.x.
7
Changes in the platelet phosphoinositides during the first minute after stimulation of washed rabbit platelets with thrombin.用凝血酶刺激洗涤过的兔血小板后第一分钟内血小板磷酸肌醇的变化。
Biochem J. 1984 Apr 1;219(1):25-31. doi: 10.1042/bj2190025.
8
Stimulation of phosphate uptake in human platelets by thrombin and collagen. Changes in specific 32P labeling of metabolic ATP and polyphosphoinositides.凝血酶和胶原蛋白对人血小板中磷酸盐摄取的刺激作用。代谢性ATP和多磷酸肌醇特异性32P标记的变化。
J Biol Chem. 1987 May 25;262(15):7047-52.
9
Synergism between thrombin and adrenaline (epinephrine) in human platelets. Marked potentiation of inositol phospholipid metabolism.凝血酶与肾上腺素在人血小板中的协同作用。肌醇磷脂代谢的显著增强。
Biochem J. 1988 Jul 15;253(2):581-6. doi: 10.1042/bj2530581.
10
Involvement of platelet glycoprotein IIb-IIIa (alpha IIb-beta 3 integrin) in thrombin-induced synthesis of phosphatidylinositol 3',4'-bisphosphate.
J Biol Chem. 1991 Dec 15;266(35):23554-7.

引用本文的文献

1
The role of inositol polyphosphate 4-phosphatase 1 in platelet function using a weeble mouse model.使用摇摆小鼠模型研究肌醇多磷酸4-磷酸酶1在血小板功能中的作用。
Adv Enzyme Regul. 2011;51(1):101-5. doi: 10.1016/j.advenzreg.2010.11.006. Epub 2010 Nov 24.
2
Tyrosine kinases and phosphoinositide metabolism in thrombin-stimulated human platelets.凝血酶刺激的人血小板中的酪氨酸激酶与磷酸肌醇代谢
Biochem J. 1993 Jun 15;292 ( Pt 3)(Pt 3):851-6. doi: 10.1042/bj2920851.
3
Defect in skeletal muscle phosphatidylinositol-3-kinase in obese insulin-resistant mice.

本文引用的文献

1
PLATELET SEQUESTRATION IN MAN. I. METHODS.人体中的血小板隔离。一、方法。
J Clin Invest. 1964 May;43(5):843-55. doi: 10.1172/JCI104970.
2
Effects of acetylcholine on the turnover of phosphoryl units in individual phospholipids of pancreas slices and brain cortex slices.乙酰胆碱对胰腺切片和大脑皮层切片中单个磷脂的磷酰基单位周转的影响。
Biochim Biophys Acta. 1955 Sep;18(1):102-10. doi: 10.1016/0006-3002(55)90013-5.
3
Extraction and purification of polyphosphoinositides.多磷酸肌醇的提取与纯化。
肥胖胰岛素抵抗小鼠骨骼肌中磷脂酰肌醇-3-激酶的缺陷。
J Clin Invest. 1993 Apr;91(4):1358-66. doi: 10.1172/JCI116337.
4
Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation.磷脂酰肌醇3激酶激活是胰岛素刺激pp70 S6激酶、DNA合成及葡萄糖转运体转位所必需的。
Mol Cell Biol. 1994 Jul;14(7):4902-11. doi: 10.1128/mcb.14.7.4902-4911.1994.
5
Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase.整合素依赖的磷酸肌醇3激酶向凝血酶激活血小板细胞骨架的转位涉及p85α与肌动蛋白丝和粘着斑激酶的特异性相互作用。
J Cell Biol. 1995 May;129(3):831-42. doi: 10.1083/jcb.129.3.831.
6
Relationship between phosphoinositide kinase activities and protein tyrosine phosphorylation in plasma membranes from A431 cells.A431细胞细胞膜中磷酸肌醇激酶活性与蛋白质酪氨酸磷酸化之间的关系。
Biochem J. 1990 Dec 15;272(3):665-70. doi: 10.1042/bj2720665.
7
Phosphorylation in vitro of the 85 kDa subunit of phosphatidylinositol 3-kinase and its possible activation by insulin receptor tyrosine kinase.磷脂酰肌醇3激酶85 kDa亚基的体外磷酸化及其可能被胰岛素受体酪氨酸激酶激活的情况。
Biochem J. 1991 Dec 15;280 ( Pt 3)(Pt 3):769-75. doi: 10.1042/bj2800769.
8
BW755C or staurosporine inhibits collagen-stimulated phosphoinositide phosphorylation in platelets.BW755C或星形孢菌素可抑制血小板中胶原刺激的磷酸肌醇磷酸化。
Lipids. 1991 Sep;26(9):689-95. doi: 10.1007/BF02535615.
9
Accumulation of PtdIns(3,4)P2 and PtdIns(3,4,5)P3 in thrombin-stimulated platelets. Different sensitivities to Ca2+ or functional integrin.凝血酶刺激的血小板中磷脂酰肌醇-3,4-二磷酸（PtdIns(3,4)P2）和磷脂酰肌醇-3,4,5-三磷酸（PtdIns(3,4,5)P3）的积累。对钙离子或功能性整合素的不同敏感性。
Biochem J. 1992 Sep 1;286 ( Pt 2)(Pt 2):581-4. doi: 10.1042/bj2860581.
Methods Enzymol. 1981;72:626-31. doi: 10.1016/s0076-6879(81)72054-8.
4
Adenosine diphosphate-induced platelet aggregation in suspensions of washed rabbit platelets.洗涤过的兔血小板悬液中，二磷酸腺苷诱导的血小板聚集。
Br J Haematol. 1970 Jul;19(1):7-17. doi: 10.1111/j.1365-2141.1970.tb01596.x.
5
Thin-layer chromatography of the phosphoinositides.磷酸肌醇的薄层层析法。
J Lipid Res. 1968 Jul;9(4):532-3.
6
p60c-src activity detected in the chromaffin granule membrane.在嗜铬粒细胞膜中检测到p60c-src活性。
Biochem Biophys Res Commun. 1986 Jan 29;134(2):736-42. doi: 10.1016/s0006-291x(86)80482-x.
7
Subcellular localization of inositol lipids in blood platelets as deduced from the use of labelled precursors.通过使用标记前体推断血小板中肌醇脂质的亚细胞定位。
Biochem J. 1987 Jun 15;244(3):757-61. doi: 10.1042/bj2440757.
8
Phosphoinositide metabolism in resting and thrombin-stimulated human platelets. Evidence against metabolic heterogeneity.静息和凝血酶刺激的人血小板中的磷酸肌醇代谢。反对代谢异质性的证据。
FEBS Lett. 1987 Jun 22;218(1):68-72. doi: 10.1016/0014-5793(87)81020-7.
9
Turnover of the phosphomonoester groups of polyphosphoinositol lipids in unstimulated human platelets.未受刺激的人血小板中多磷酸肌醇脂质磷酸单酯基团的周转
Eur J Biochem. 1987 Jul 1;166(1):3-9. doi: 10.1111/j.1432-1033.1987.tb13475.x.
10
PDGF modifies phosphoinositide metabolism and inhibits aggregation and release in human platelets.
Biochem Biophys Res Commun. 1986 Feb 26;135(1):52-7. doi: 10.1016/0006-291x(86)90941-1.