半同种异体嵌合体中的原发性抗病毒细胞毒性T细胞反应并非绝对局限于宿主H-2类型。
Primary anti-viral cytotoxic T-cell responses in semiallogeneic chimeras are not absolutely restricted to host H-2 type.
作者信息
Blanden R V, Andrew M E
出版信息
J Exp Med. 1979 Feb 1;149(2):535-8. doi: 10.1084/jem.149.2.535.
Abstract
Chimeras produced by reconstitution of 950 rads irradiated type A or type B host mice with (AXB)F1 fetal liver stem cells were examined in primary (in vivo) and secondary (in vitro) Tc-cell responses to ectromelia virus infection. Of 33 individual chimeras which gave primary responses, 26 produced significant specific lysis of infected targets of both A and B type, though host type targets were invariably lysed more efficiently (host bias). The other 7 chimeras gave lysis of infected host type targets only (absolute restriction). 12 individual chimeras were used in secondary responses. Nine showed host bias, and three showed absolute restriction. Whether an individual chimera showed host bias or absolute restriction seemed to be unrelated to whether the response was primary or secondary, to the time after reconstitution (ranging from 4 to 22 wk), to strain of mouse, or to the batch of fetal liver stem cells used.
摘要
用（AXB）F1胎肝干细胞重建经950拉德辐照的A型或B型宿主小鼠所产生的嵌合体，在针对痘苗病毒感染的初次（体内）和二次（体外）Tc细胞反应中进行了检测。在产生初次反应的33个个体嵌合体中，26个对A型和B型感染靶标产生了显著的特异性裂解，尽管宿主型靶标总是被更有效地裂解（宿主偏向）。另外7个嵌合体仅对感染的宿主型靶标产生裂解（绝对限制）。12个个体嵌合体用于二次反应。9个表现出宿主偏向，3个表现出绝对限制。个体嵌合体表现出宿主偏向还是绝对限制，似乎与反应是初次还是二次、重建后的时间（4至22周）、小鼠品系或所用胎肝干细胞批次无关。
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Primary anti-viral cytotoxic T-cell responses in semiallogeneic chimeras are not absolutely restricted to host H-2 type.半同种异体嵌合体中的原发性抗病毒细胞毒性T细胞反应并非绝对局限于宿主H-2类型。
J Exp Med. 1979 Feb 1;149(2):535-8. doi: 10.1084/jem.149.2.535.
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本文引用的文献
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Current concepts of the immunological function of the thymus.胸腺免疫功能的当前概念。
Physiol Rev. 1967 Jul;47(3):437-520. doi: 10.1152/physrev.1967.47.3.437.
2
Cell-medicated cytotoxicity against ectromelia virus-infected target cells. III. Role of the H-2 gene complex.细胞介导的针对感染痘苗病毒的靶细胞的细胞毒性。III. H-2基因复合体的作用。
Eur J Immunol. 1975 Feb;5(2):122-7. doi: 10.1002/eji.1830050210.
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Major histocompatibility complex-linked immune-responsiveness is acquired by lymphocytes of low-responder mice differentiating in thymus of high-responder mice.主要组织相容性复合体相关的免疫反应性是由低反应性小鼠的淋巴细胞在高反应性小鼠的胸腺中分化而获得的。
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On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?关于胸腺在T细胞“组织相容性-2自身识别”分化中的作用：双重识别的证据？
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In a radiation chimaera, host H-2 antigens determine immune responsiveness of donor cytotoxic cells.在辐射嵌合体中，宿主H-2抗原决定供体细胞毒性细胞的免疫反应性。
Nature. 1977 Sep 29;269(5627):417-8. doi: 10.1038/269417a0.
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In vitro primary induction of cytotoxic T cells against virus-infected syngeneic cells.针对病毒感染的同基因细胞的细胞毒性T细胞的体外初次诱导。
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The cell-mediated immune response to ectromelia virus infection. II. Secondary response in vitro and kinetics of memory T cell production in vivo.对痘苗病毒感染的细胞介导免疫反应。II. 体外二次反应及体内记忆性T细胞产生的动力学
Cell Immunol. 1976 Mar 15;22(2):283-96. doi: 10.1016/0008-8749(76)90030-7.
8
A dual recognition model for cytotoxic T cells based on thymic selection of precursors with low affinity for Self H-2 antigens.基于对自身H-2抗原亲和力低的前体细胞的胸腺选择的细胞毒性T细胞双识别模型。
Scand J Immunol. 1978 Mar;7(3):181-90. doi: 10.1111/j.1365-3083.1978.tb00442.x.
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Two different VH gene products make up the T-cell receptors.两种不同的重链可变区基因产物构成了T细胞受体。
Scand J Immunol. 1976;5(9):993-1001. doi: 10.1111/j.1365-3083.1976.tb03051.x.
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