Department of Ecology and Evolution, Biophore, Swiss Institute of Bioinformatics, Lausanne University, CH-1015 Lausanne, Switzerland.
Brief Bioinform. 2011 Sep;12(5):436-41. doi: 10.1093/bib/bbr031. Epub 2011 Jun 15.
Despite the common assumption that orthologs usually share the same function, there have been various reports of divergence between orthologs, even among species as close as mammals. The comparison of mouse and human is of special interest, because mouse is often used as a model organism to understand human biology. We review the literature on evidence for divergence between human and mouse orthologous genes, and discuss it in the context of biomedical research.
尽管普遍认为直系同源物通常具有相同的功能，但也有各种关于直系同源物之间分化的报道，即使在哺乳动物等亲缘关系较近的物种中也是如此。比较小鼠和人类特别有趣，因为小鼠通常被用作模型生物来理解人类生物学。我们综述了关于人类和小鼠直系同源基因分化的证据，并在生物医学研究的背景下进行了讨论。
