About I
Laboratoire Interface Matrice Extracellulaire-Biomatériaux, Faculté d'Odontologie, Université de la Méditerranée, Marseille, France.
Adv Dent Res. 2011 Jul;23(3):320-4. doi: 10.1177/0022034511405324.
The elaboration of dentin-pulp engineering strategies requires the investigation of not only progenitor cell potentials but also their interactions with other non-progenitor "supportive" cells. Under severe caries lesions, progenitor cells may be activated by growth factors released after the acidic dissolution of carious dentin. However, dentin regeneration has also been observed after traumatic injuries without any significant dentin dissolution. This raises questions about the origin of signals involved in progenitor cell activation, migration, and differentiation. Study models such as the entire tooth culture and co-cultures of pulp and endothelial cells highlighted the role of interactions between the different pulp cell types and the pivotal role they play in dentin regeneration. Injured pulp fibroblasts secrete growth factors involved in progenitor cell activation and differentiation as well as neoangiogenesis which may pave the pathways for progenitor cell migration. This appears to be the first paper to focus on this very important field in dental pulp biology.
牙本质-牙髓工程策略的制定不仅需要研究祖细胞的潜能，还需要研究它们与其他非祖细胞“支持性”细胞的相互作用。在严重的龋损情况下，祖细胞可能会被龋坏牙本质酸性溶解后释放的生长因子激活。然而，在没有任何明显牙本质溶解的创伤性损伤后也观察到了牙本质再生。这就引发了关于参与祖细胞激活、迁移和分化的信号来源的问题。诸如全牙培养以及牙髓细胞与内皮细胞共培养等研究模型突出了不同牙髓细胞类型之间相互作用的作用以及它们在牙本质再生中所起的关键作用。受损的牙髓成纤维细胞分泌参与祖细胞激活、分化以及新血管生成的生长因子，这可能为祖细胞迁移铺平道路。这似乎是第一篇聚焦牙髓生物学这一非常重要领域的论文。
