Chmilewsky Fanny, Jeanneau Charlotte, Dejou Jacques, About Imad
Aix Marseille Université, Centre National de la Recherche Scientifique, Institut des Sciences du Movement Unité Mixte de Recherche 7287, Marseille, France.
Aix Marseille Université, Centre National de la Recherche Scientifique, Institut des Sciences du Movement Unité Mixte de Recherche 7287, Marseille, France; Service d'Odontologie, Assistance Publique-Hopitaux de Marseille, Hôpital Timone, Marseille, France.
J Endod. 2014 Apr;40(4 Suppl):S19-25. doi: 10.1016/j.joen.2014.01.012.
Many aspects of dentin pulp tissue regeneration have been investigated, and it has been shown that dentin pulp has a high regeneration capacity. This seems to be because of the presence of progenitor cells and inductive regeneration signals from different origins. These signals can be liberated after the acidic dissolution of carious dentin as well as from pulp fibroblasts and endothelial cells in cases of traumatic injury. Thus, both carious lesions and pulp cells provide the required mediators for complete dentin-pulp regeneration including reparative dentin secretion, angiogenesis, and innervation. Additionally, all dentin pulp insults including carious "infection," traumatic injuries, application of restorative materials on the injured dentin pulp, and subsequent apoptosis are known activators of the complement system. This activation leads to the production of several biologically active fragments responsible for the vascular modifications and the attraction of immune cells to the inflammatory/injury site. Among these, C5a is involved in the recruitment of pulp progenitor cells, which express the C5a receptor. Thus, in addition to dentin and pulp cells, plasma should be considered as an additional source of regeneration signals.
牙本质牙髓组织再生的许多方面已被研究，并且已经表明牙本质牙髓具有很高的再生能力。这似乎是由于祖细胞的存在以及来自不同来源的诱导性再生信号。这些信号在龋坏牙本质酸溶解后以及在创伤性损伤情况下从牙髓成纤维细胞和内皮细胞中释放出来。因此，龋损和牙髓细胞都为包括修复性牙本质分泌、血管生成和神经支配在内的完整牙本质 - 牙髓再生提供所需的介质。此外，所有牙本质牙髓损伤，包括龋坏“感染”、创伤性损伤、在受伤的牙本质牙髓上应用修复材料以及随后的细胞凋亡，都是补体系统的已知激活剂。这种激活导致产生几种负责血管改变和免疫细胞向炎症/损伤部位募集的生物活性片段。其中，C5a参与牙髓祖细胞的募集，这些祖细胞表达C5a受体。因此，除了牙本质和牙髓细胞外，血浆也应被视为再生信号的额外来源。
