School of Chemistry, University of Southampton, Highfield, Southampton SO171BJ, UK.
Molecules. 2011 Jun 15;16(6):4912-22. doi: 10.3390/molecules16064912.
We describe the synthesis of terpyridine modified DNA strands which selectively form DNA nanotubes through orthogonal hydrogen bonding and metal complexation interactions. The short DNA strands are designed to self-assemble into long duplexes through a sticky-end approach. Addition of weakly binding metals such as Zn(II) and Ni(II) induces the formation of tubular arrays consisting of DNA bundles which are 50-200 nm wide and 2-50 nm high. TEM shows additional long distance ordering of the terpy-DNA complexes into fibers.
我们描述了通过正交氢键和金属配位相互作用选择性形成 DNA 纳米管的三吡啶基修饰 DNA 链的合成。这些短的 DNA 链被设计成通过粘性末端方法自组装成长的双链体。添加弱结合金属如 Zn(II)和 Ni(II)会诱导由 DNA 束组成的管状阵列的形成，这些 DNA 束的宽度为 50-200nm，高度为 2-50nm。TEM 显示了三吡啶基-DNA 配合物进一步的长程纤维状有序排列。
