Department of Chemistry, New York University, New York, New York 10003, USA.
Nano Lett. 2010 Jun 9;10(6):1971-8. doi: 10.1021/nl101262u.
During the past decade, the field of structural DNA nanotechnology has grown enormously, not only in the number of its participants but also qualitatively in its capabilities. A number of goals evident in 2001 have been achieved: These include the extension of self-assembled crystalline systems from 2D to 3D and the achievement of 2D algorithmic assembly. A variety of nanoscale walking devices have been developed. A key unanticipated development was the advent of DNA origami, which has vastly expanded the scale of addressable DNA structures. Nanomechanical devices have been incorporated into 2D arrays, and into 2D origami structures, as well, leading to capture systems and to a nanomechanical assembly line. DNA has been used to scaffold non-DNA species, so that one of its key goals has been achieved. Biological replication of DNA nanostructures with simple topologies has also been accomplished. The increase in the number of participants in the enterprise holds great promise for the coming decade.
在过去的十年中，结构 DNA 纳米技术领域的发展非常迅速，不仅参与者的数量增加了，而且在能力上也有了质的提高。2001 年提出的一些目标已经实现：其中包括将自组装晶体系统从 2D 扩展到 3D，并实现 2D 算法组装。已经开发出了各种纳米级步行设备。一个意想不到的关键发展是 DNA 折纸术的出现，它极大地扩展了可寻址 DNA 结构的规模。纳米机械装置已被纳入 2D 阵列，以及 2D 折纸结构，从而形成了捕获系统和纳米机械装配线。DNA 已被用于支撑非 DNA 物质，因此其关键目标之一已经实现。具有简单拓扑结构的 DNA 纳米结构的生物复制也已完成。该领域参与者数量的增加为未来十年带来了巨大的希望。
