Li D C
Department of Pathology, PUMC Hospital, Beijing.
Zhonghua Bing Li Xue Za Zhi. 1990 Jun;19(2):116-8.
With DNA-mRNA hybridization in situ technique, the expression of five oncogenes, c-N-ras, c-K-ras, c-H-ras, c-myc and c-fos, was observed in two cases of human hepatocellular carcinoma. The expression of c-N-ras, c-fos was greatly enhanced in tumor tissues of the two cases, and about 25%-50% of the tumor cells showed positive expression. The other three oncogenes namely c-K-ras, c-H-ras and c-myc, were not detected in these two carcinomas or the non-cancerous liver tissue adjacent to the carcinomas. It is surmised that c-N-ras and c-fos may play coordinative role in maintaining the malignant phenotype of human primary hepatocellular carcinoma.
应用DNA-mRNA原位杂交技术，观察了两例人肝细胞癌中5种癌基因c-N-ras、c-K-ras、c-H-ras、c-myc和c-fos的表达情况。两例肿瘤组织中c-N-ras、c-fos的表达明显增强，约25%-50%的肿瘤细胞呈阳性表达。另外3种癌基因，即c-K-ras、c-H-ras和c-myc，在这两例癌组织及癌旁非癌肝组织中均未检测到。推测c-N-ras和c-fos可能在维持人原发性肝细胞癌的恶性表型中起协同作用。
