Carleton S A, Brown W F
J Neurol Neurosurg Psychiatry. 1979 Jan;42(1):42-51. doi: 10.1136/jnnp.42.1.42.
In motor neurone disease changes in the functional properties of motor units, including the surface voltage, latency, conduction velocity, and response to repetitive stimulation, were investigated. Progression was marked by motor unit loss, increase in the proportion of larger motor unit potentials, and inclusion of motor unit potentials larger than normal in the remaining motor unit population. Even late in the disease, motor unit potentials with a low surface voltage persisted. The relationship between motor unit potentials, surface voltage, and latency, present in control subjects, broke down in motor neurone disease, large motor unit potentials having abnormally long latencies and small motor unit potentials unexpectedly short latencies. Amplitude decrements were more frequent and severe in motor unit potentials at later stages in the disease, particularly in those units with lower surface voltages. In one surviving motor unit potential there was evidence suggestive of functional recovery. The observations point to complex changes in the functional properties of motor units in motor neurone disease.
对运动神经元病中运动单位功能特性的变化进行了研究，这些特性包括表面电压、潜伏期、传导速度以及对重复刺激的反应。疾病进展的特征为运动单位丧失、较大运动单位电位比例增加，以及在剩余运动单位群体中出现大于正常的运动单位电位。即使在疾病晚期，仍存在表面电压较低的运动单位电位。在对照组中存在的运动单位电位、表面电压和潜伏期之间的关系，在运动神经元病中被打破，大运动单位电位的潜伏期异常延长，而小运动单位电位的潜伏期意外缩短。在疾病后期，运动单位电位的幅度递减更为频繁和严重，尤其是那些表面电压较低的单位。在一个存活的运动单位电位中，有证据表明存在功能恢复。这些观察结果表明运动神经元病中运动单位的功能特性发生了复杂变化。
