Goñi-Moreno Angel, Amos Martyn
School of Computing, Mathematics and Digital Technology, Manchester Metropolitan University, Manchester, UK.
Biosystems. 2011 Sep;105(3):286-94. doi: 10.1016/j.biosystems.2011.05.011. Epub 2011 Jun 6.
Genetic oscillators are a major theme of interest in the emerging field of synthetic biology. Until recently, most work has been carried out using intra-cellular oscillators, but this approach restricts the broader applicability of such systems. Motivated by a desire to develop large-scale, spatially distributed cell-based computational systems, we present an initial design for a population-level oscillator which uses three different bacterial strains. Our system is based on the client-server model familiar to computer science, and uses quorum sensing for communication between nodes. Importantly, it is robust to perturbation and noise. We present the results of extensive in silico simulation tests, which confirm the feasibility of our design.
遗传振荡器是合成生物学新兴领域中一个主要的研究热点。直到最近，大多数研究工作都是使用细胞内振荡器来开展的，但这种方法限制了此类系统更广泛的适用性。出于开发大规模、空间分布的基于细胞的计算系统的愿望，我们提出了一种基于三种不同细菌菌株的群体水平振荡器的初步设计。我们的系统基于计算机科学中熟悉的客户端 - 服务器模型，并使用群体感应进行节点间通信。重要的是，它对干扰和噪声具有鲁棒性。我们展示了广泛的计算机模拟测试结果，这些结果证实了我们设计的可行性。
