Bendriss L, Lebbaq A, Jallal H, Mrani S, Khatouri A
Cardiology clinic of military hospital, Marrakech, Morocco.
Ann Cardiol Angeiol (Paris). 2012 Feb;61(1):15-9. doi: 10.1016/j.ancard.2011.04.011. Epub 2011 May 25.
Increased urinary albumin-excretion is a cardiovascular risk factor. The metabolic syndrome is associated with an increased risk of chronic kidney disease, cardiovascular disease and mortality. The aim of this prospective study was to explore the combined associations of microalbuminuria and metabolic syndrome with the risk of incident cardiovascular disease.
The present study involved 78 patients with metabolic syndrome between May 1 and July 30 in 2009 from cardiology clinic of military hospital in Marrakech. They were followed for 1 year. The metabolic syndrome was defined according to the criteria of International Diabetes Federation (IDF). Microalbuminuria was defined as a urinary albumin excretion of 30 to 300mg/d.
The mean age was 56 years old. The prevalence of microalbuminuria was 38%. There was a significantly positive correlation between the number of components of the metabolic syndrome and the corresponding prevalence of microalbuminuria. Incidence rates of cardiovascular events were higher in the positive microalbuminuria group than the group without microalbuminuria, the difference was significant for composite criteria but not for each one probably because of the small size of effective and limited duration.
There is a strong relationship between microalbuminuria and the metabolic syndrome. Microalbuminuria accounts for the increased risk of cardiovascular disease in patients with metabolic syndrome.
尿白蛋白排泄增加是一种心血管危险因素。代谢综合征与慢性肾脏病、心血管疾病及死亡风险增加相关。这项前瞻性研究的目的是探讨微量白蛋白尿和代谢综合征与心血管疾病发病风险的联合关联。
本研究纳入了2009年5月1日至7月30日期间来自马拉喀什一家军事医院心脏病科门诊的78例代谢综合征患者。对他们进行了为期1年的随访。代谢综合征根据国际糖尿病联盟（IDF）的标准定义。微量白蛋白尿定义为尿白蛋白排泄量为30至300mg/d。
平均年龄为56岁。微量白蛋白尿的患病率为38%。代谢综合征的组分数量与微量白蛋白尿的相应患病率之间存在显著正相关。微量白蛋白尿阳性组的心血管事件发生率高于无微量白蛋白尿组，对于综合标准差异有统计学意义，但对于每个标准差异无统计学意义，可能是因为样本量小且随访时间有限。
微量白蛋白尿与代谢综合征之间存在密切关系。微量白蛋白尿是代谢综合征患者心血管疾病风险增加的原因。
