Department of Nutrition and Food Science, University of the Basque Country, Vitoria, Spain.
Obesity (Silver Spring). 2012 Feb;20(2):376-81. doi: 10.1038/oby.2011.160. Epub 2011 Jun 16.
We examined whether birth weight (BW) predicts changes in body composition over a 6-year period in Swedish children and adolescents. For this purpose, a total of 247 children (55.5% girls) and 162 adolescents (60.5% girls) were included in the study and were followed up 6 years later. BW was obtained from parental records. We measured weight, height, waist circumference, and the bicep, tricep, subscapular, suprailiac, and medial calf skinfolds, and we calculated BMI, fat-free mass (FFM), and the sum of five skinfolds. Physical activity was assessed by accelerometry. Changes in pubertal status and baseline anthropometric estimates were used as confounders in all analysis. In the children cohort, we observed that BW was inversely associated with changes in BMI (β = -0.736, P = 0.002) and the sum of five skinfolds (β = -6.381, P = 0.009) regardless of confounders and physical activity, only in girls. We did not find any significant association between BW and adiposity gain estimates in the adolescent cohort. These findings give further support to the concept that low BW may have a programming effect of subsequent adiposity gain from childhood to adolescence. We also confirm the sex-related differences in the programming effect of body composition.
我们研究了出生体重 (BW) 是否能预测瑞典儿童和青少年在 6 年内身体成分的变化。为此，共有 247 名儿童（55.5%为女孩）和 162 名青少年（60.5%为女孩）纳入研究，并在 6 年后进行了随访。BW 来自父母记录。我们测量了体重、身高、腰围以及肱二头肌、肱三头肌、肩胛下、髂嵴上和小腿内侧皮褶厚度，并计算了 BMI、去脂体重 (FFM) 和 5 个皮褶厚度的总和。身体活动通过加速度计进行评估。在所有分析中，青春期状态和基线人体测量估计的变化被用作混杂因素。在儿童队列中，我们观察到，无论混杂因素和身体活动如何，BW 与 BMI（β=-0.736，P=0.002）和 5 个皮褶厚度总和（β=-6.381，P=0.009）的变化呈负相关，仅在女孩中。我们在青少年队列中没有发现 BW 与肥胖增加估计之间的任何显著关联。这些发现进一步支持了低 BW 可能对从儿童期到青春期的随后肥胖增加具有编程作用的概念。我们还证实了身体成分编程效应的性别差异。
