Kang Myunggee, Yoo Jung Eun, Kim Kyuwoong, Choi Seulggie, Park Sang Min
Department of Biomedical Science, Seoul National University Graduate School, Seoul, Korea.
Department of Industrial Engineering, Seoul National University College of Engineering, Seoul, Korea.
BMJ Open. 2018 Feb 24;8(2):e018039. doi: 10.1136/bmjopen-2017-018039.
Previous studies on the relationship between birth weight and obesity in adolescents have mostly been conducted within Western populations and have yielded inconsistent results. We aimed to investigate the association between birth weight, obesity, fat mass and lean mass in Korean adolescents using the fifth Korea National Health and Nutritional Examination Survey (KNHANES V).
The study population consisted of a total of 1304 (693 men and 611 women) participants aged between 12 and 18 years. Adjusted ORs and 95% CIs were calculated by multivariable logistic regression analyses to determine the association between birth weight and being overweight or obese. Furthermore, adjusted mean values for body mass index (BMI), fat mass index (FMI) and lean mass index (LMI) according to birth weight were calculated by multiple linear regression analyses.
Individuals within the highest 25th percentile in birth weight were more likely to be overweight (adjusted OR (aOR) 1.75, 95% CI 1.11 to 2.76) compared with adolescents within the 25th and 75th percentile in birth weight. Female adolescents who were in the highest 25th percentile in birth weight were more likely to be obese (aOR 2.13, 95% CI 1.03 to 4.41) compared with those within the 25th and 75th percentile in birth weight. Increasing FMI, but not LMI was associated with increasing birth weight (P for trend: 0.03). This tendency remained only in female population in sex-stratified analysis (P for trend: 0.03).
High birth weight may lead to obesity and increased fat mass, but not lean mass. Adolescents born with high birth weight may benefit from close weight monitoring and early intervention against obesity.
以往关于青少年出生体重与肥胖之间关系的研究大多在西方人群中进行，结果并不一致。我们旨在利用第五次韩国国家健康与营养检查调查（KNHANES V）来研究韩国青少年出生体重、肥胖、脂肪量和去脂体重之间的关联。
研究人群共有1304名（693名男性和611名女性）年龄在12至18岁之间的参与者。通过多变量逻辑回归分析计算调整后的比值比（OR）和95%可信区间（CI），以确定出生体重与超重或肥胖之间的关联。此外，通过多元线性回归分析计算根据出生体重的体重指数（BMI）、脂肪量指数（FMI）和去脂体重指数（LMI）的调整均值。
出生体重处于最高第25百分位数的个体与出生体重处于第25和第75百分位数之间的青少年相比，更有可能超重（调整后的OR（aOR）为1.75，95%CI为1.11至2.76）。出生体重处于最高第25百分位数的女性青少年与出生体重处于第25和第75百分位数之间的女性青少年相比，更有可能肥胖（aOR为2.13，95%CI为1.03至4.41）。FMI增加，但LMI增加与出生体重增加无关（趋势P值：0.03）。在按性别分层分析中，这种趋势仅在女性人群中存在（趋势P值：0.03）。
高出生体重可能导致肥胖和脂肪量增加，但不会导致去脂体重增加。出生体重高的青少年可能受益于密切的体重监测和早期肥胖干预。
