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Mohs 显微外科治疗侵袭性和复发性面部基底细胞癌的 5 年复发率。

5-year recurrence rates of Mohs micrographic surgery for aggressive and recurrent facial basal cell carcinoma.

机构信息

Department of Dermatology and Venereology, Sahlgrenska University Hospital, Institute of Clinical Sciences at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

出版信息

Acta Derm Venereol. 2011 Oct;91(6):689-93. doi: 10.2340/00015555-1134.

Abstract

Mohs micrographic surgery allows for complete microscopic examination of the surgical margin when treating aggressive and recurrent facial basal cell carcinomas. This leads to the highest cure rates and maximal preservation of healthy tissue. The 5-year recurrence rates of 587 aggressive and/or recurrent facial basal cell carcinomas treated during 1993 to 2003 at our centre were studied retrospectively. The resulting 5-year recurrence rates using Kaplan-Meier survival analysis were 2.1% for primary (previously untreated) tumours, 5.2% for recurrent basal cell carcinomas and 3.3% overall. In total, 87.9% of the tumours required at least two stages of Mohs micrographic surgery. The surgical defect's size after complete excision was, on average, approximately twice the size of the defect after excision of the clinically visible tumour with a 2-3 mm margin. Mohs micro-graphic surgery is underused in Scandinavia despite being the treatment of choice for aggressive and recurrent facial basal cell carcinomas.

摘要

Mohs 显微外科手术在治疗侵袭性和复发性面部基底细胞癌时允许对手术切缘进行完全的显微镜检查。这可实现最高的治愈率和最大限度地保留健康组织。对 1993 年至 2003 年期间在我们中心治疗的 587 例侵袭性和/或复发性面部基底细胞癌进行了回顾性研究。使用 Kaplan-Meier 生存分析得出的 5 年复发率为:原发性(未治疗过)肿瘤为 2.1%,复发性基底细胞癌为 5.2%,总体为 3.3%。总共,87.9%的肿瘤需要至少两个阶段的 Mohs 显微外科手术。完全切除后的手术缺损平均大小约为切除临床可见肿瘤并带有 2-3mm 切缘后的缺损的两倍。尽管 Mohs 显微外科手术是治疗侵袭性和复发性面部基底细胞癌的首选方法,但在斯堪的纳维亚半岛的应用仍不充分。

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