铜绿假单胞菌喹诺酮耐药菌株中DNA促旋酶突变体的比例。
Proportion of DNA gyrase mutants among quinolone-resistant strains of Pseudomonas aeruginosa.
作者信息
Yoshida H, Nakamura M, Bogaki M, Nakamura S
机构信息
Research Laboratories, Dainippon Pharmaceutical Co., Ltd., Osaka, Japan.
出版信息
Antimicrob Agents Chemother. 1990 Jun;34(6):1273-5. doi: 10.1128/AAC.34.6.1273.
Abstract
The proportion of DNA gyrase mutants among quinolone-resistant strains of Pseudomonas aeruginosa was examined by introducing the cloned wild-type Escherichia coli gyrA and gyrB genes. Of 101 spontaneous mutants of P. aeruginosa PAO505, 33 (33%) were found to have gyrA mutations. Among 17 clinical isolates, 12 (71%) had gyrA mutations and 1 (6%) had a gyrB mutation.
摘要
通过导入克隆的野生型大肠杆菌gyrA和gyrB基因，检测了铜绿假单胞菌喹诺酮耐药菌株中DNA促旋酶突变体的比例。在铜绿假单胞菌PAO505的101个自发突变体中，发现33个（33%）有gyrA突变。在17个临床分离株中，12个（71%）有gyrA突变，1个（6%）有gyrB突变。
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