Kovács L, Lichardus B, Benetínová J, Orbanová Z, Bircák J
Katedry pediatrie I LFUK v Bratislave.
Bratisl Lek Listy. 1990 Jun;91(6):423-32.
Endogenous digoxin-like substance (EDLS) in urine has been considered to be the representative of the natriuretic hormone, the endogenous inhibitor of the sodium pump (the sodium-potassium transporting enzyme Na, K-ATPase). Its site of production remains unknown, and so does its chemical nature. It has been suggested however that EDLS and the atrial natriuretic factor represent two distinct natriuretic system. Although the present work does not provide evidence for EDLS to be a natriuretic hormone, it nevertheless supplies data in support of this hypothesis. In preterm neonates, the decreased sodium excretion during the first days of life is accompanied by a parallel decrease in urinary EDLS excretion. The same was observed in a group of children from the infant period through the age of 12-14 years. Both parameters showed in parallel the lowest values in the oldest children examined. Children aged 8-12 years also showed parallel excretion of sodium and ELDS, even if natriuresis was induced in recumbent position and antinatriuresis in upright position. When the children remained recumbent for 24 h there were no differences in sodium and EDLS excretion between daytime and night. Children involved in adequate physical activities during daytime excreted less sodium and EDLS during the day than at night.
尿中的内源性洋地黄样物质（EDLS）被认为是利钠激素的代表，是钠泵（钠钾转运酶Na，K - ATP酶）的内源性抑制剂。其产生部位尚不清楚，化学性质也不清楚。然而，有人提出EDLS和心房利钠因子代表两个不同的利钠系统。尽管目前的研究没有为EDLS是一种利钠激素提供证据，但它仍然提供了支持这一假设的数据。在早产儿中，出生后最初几天钠排泄减少，同时尿EDLS排泄也相应减少。在一组从婴儿期到12 - 14岁的儿童中也观察到了同样的情况。在接受检查的年龄最大的儿童中，这两个参数都同时显示出最低值。8 - 12岁的儿童即使在卧位时引起利钠，立位时引起钠潴留，钠和ELDS的排泄也呈现平行关系。当儿童保持卧位24小时时，白天和夜间的钠和EDLS排泄没有差异。白天进行适量体育活动的儿童，白天的钠和EDLS排泄量比夜间少。
