Takahashi H, Matsusawa M, Okabayashi H, Suga K, Ikegaki I, Nishimura M, Yoshimura M
Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Am J Hypertens. 1988 Jul;1(3 Pt 3):168S-172S. doi: 10.1093/ajh/1.3.168s.
Possible involvement of an endogenous digitalislike substance (EDLS) in blood pressure regulation was investigated using a Japanese population. Mean arterial pressure (MAP) significantly correlated with urinary excretion of the EDLS, age, and the obesity index. The plasma EDLS correlated with urinary EDLS. Urinary EDLS excretion well correlated with the inhibitory activity on Na+,K+-ATPase, and also with the urinary excretion of NaCl. Obesity index correlated with the Na+,K+-ATPase inhibition and arterial pressure. Although plasma content of atrial natriuretic polypeptide correlated with the urinary Na+,K+-ATPase inhibition, it did not correlate with the rest of all parameters. Plasma vasopressin level did not correlate with these parameters either. These results clearly indicate that the circulating EDLS (ie, Na+,K+-ATPase inhibitor) is implicated in the hypertension associated with an excess intake of sodium, aging and obesity.
利用日本人群研究了内源性类洋地黄物质（EDLS）在血压调节中的可能作用。平均动脉压（MAP）与EDLS的尿排泄量、年龄及肥胖指数显著相关。血浆EDLS与尿EDLS相关。尿EDLS排泄量与对Na +，K + -ATP酶的抑制活性以及NaCl的尿排泄量密切相关。肥胖指数与Na +，K + -ATP酶抑制及动脉压相关。虽然心房利钠多肽的血浆含量与尿Na +，K + -ATP酶抑制相关，但与其他所有参数均无相关性。血浆血管加压素水平与这些参数也无相关性。这些结果清楚地表明，循环中的EDLS（即Na +，K + -ATP酶抑制剂）与钠摄入过多、衰老及肥胖相关的高血压有关。
