Department of Psychology, Yale University, USA.
J Affect Disord. 2011 Nov;134(1-3):416-20. doi: 10.1016/j.jad.2011.05.016. Epub 2011 Jun 17.
Few studies have prospectively examined the relationships of sleep with symptoms and functioning in bipolar disorder.
The present study examined concurrent and prospective associations between total sleep time (TST) and sleep variability (SV) with symptom severity and functioning in a cohort of DSM-IV bipolar patients (N = 468) participating in the National Institute of Mental Health Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD), all of whom were recovered at study entry.
Concurrent associations at study entry indicated that shorter TST was associated with increased mania severity, and greater SV was associated with increased mania and depression severity. Mixed-effects regression modeling was used to examine prospective associations in the 196 patients for whom follow-up data were available. Consistent with findings at study entry, shorter TST was associated with increased mania severity, and greater SV was associated with increased mania and depression severity over 12 months.
These findings highlight the importance of disrupted sleep patterns in the course of bipolar illness.
很少有研究前瞻性地检查睡眠与双相情感障碍症状和功能的关系。
本研究在 DSM-IV 双相情感障碍患者（N=468）队列中检查了总睡眠时间（TST）和睡眠变异性（SV）与症状严重程度和功能的并发和前瞻性关联，所有患者在研究开始时均已康复。
研究开始时的并发关联表明，TST 较短与躁狂严重程度增加有关，SV 较大与躁狂和抑郁严重程度增加有关。混合效应回归模型用于分析 196 名有随访数据的患者的前瞻性关联。与研究开始时的发现一致，TST 较短与躁狂严重程度增加有关，SV 较大与躁狂和抑郁严重程度在 12 个月内增加有关。
这些发现强调了睡眠模式紊乱在双相情感障碍病程中的重要性。
