Joubert A, Vogin G, Devic C, Granzotto A, Viau M, Maalouf M, Thomas C, Colin C, Foray N
Société Magelis, lotissement Bel-Air, 6 rue Frédéric-Mistral, Cadenet, France.
Cancer Radiother. 2011 Aug;15(5):348-54. doi: 10.1016/j.canrad.2011.05.001. Epub 2011 Jun 16.
At the beginning of the 21st century, radiation biology is at a major turning point in its history. It must meet the expectations of the radiation oncologists, radiologists and the general public, but its purpose remains the same: to understand the molecular, cellular and tissue levels of lethal and carcinogenic effects of ionizing radiation in order to better protect healthy tissues and to develop treatments more effective against tumours. Four major aspects of radiobiology that marked this decade will be discussed: technological developments, the importance of signalling and repair of radiation-induced deoxyribonucleic acid (DNA) damage, the impact of individual factor in the response to radiation and the contribution of radiobiology to better choose innovative therapies such as protontherapy or stereotactic body radiation therapy (SBRT). A translational radiobiology should emerge with the help of radiotherapists and radiation physicists and by facilitating access to the new radio and/or chemotherapy modalities.
在21世纪初，辐射生物学正处于其历史上的一个重大转折点。它必须满足放射肿瘤学家、放射科医生和普通公众的期望，但其目的仍然不变：了解电离辐射在分子、细胞和组织水平上的致死和致癌作用，以便更好地保护健康组织，并开发出更有效的肿瘤治疗方法。将讨论标志这十年的放射生物学的四个主要方面：技术发展、辐射诱导的脱氧核糖核酸（DNA）损伤的信号传导和修复的重要性、个体因素在辐射反应中的影响以及放射生物学对更好地选择创新疗法（如质子治疗或立体定向体部放射治疗（SBRT））的贡献。借助放射治疗师和放射物理学家，并通过促进获得新的放疗和/或化疗方式，应会出现转化放射生物学。
