Liu Jia, Zhu Hongcheng, Yang Xi, Ge Yangyang, Zhang Chi, Qin Qin, Lu Jing, Zhan Liangliang, Cheng Hongyan, Sun Xinchen
Department of Radiation Oncology, The First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Rd, Nanjing, 210029, China.
Tumour Biol. 2014 May;35(5):3975-9. doi: 10.1007/s13277-014-1623-8. Epub 2014 Jan 21.
MicroRNAs (miRNAs) represent an important nonprotein part of the human genome in tumor biology. Among the several types of miRNAs, microRNA-21 (miR-21) is dysregulated in several types of cancer and plays a key role in carcinogenesis, recurrence, and metastasis. Thus, it can be a potential target for cancer therapy including radiation therapy. In this review, we focus on miR-21, which has been identified in human cancer tissues, to suggest reasonable strategies for future research. miR-21 may have an influence on cell cycle, DNA damage repair, apoptosis, autophagy, and hypoxia of cancer during irradiation. We review the use of miR-21 in cancer radiation therapy and describe the known functions and possible underlying molecular mechanisms of miR-21 in radiosensitivity and radioresistance. Furthermore, the current and potential future applications of miR-21 in cancer radiation therapy are also discussed.
微小RNA（miRNA）是肿瘤生物学中人类基因组重要的非蛋白质组成部分。在几种类型的miRNA中，微小RNA-21（miR-21）在多种癌症中表达失调，并在致癌、复发和转移中起关键作用。因此，它可能成为包括放射治疗在内的癌症治疗的潜在靶点。在本综述中，我们聚焦于已在人类癌症组织中鉴定出的miR-21，以提出未来研究的合理策略。miR-21可能在辐射过程中对癌症的细胞周期、DNA损伤修复、凋亡、自噬和缺氧产生影响。我们综述了miR-21在癌症放射治疗中的应用，并描述了miR-21在放射敏感性和放射抗性方面已知的功能及可能的潜在分子机制。此外，还讨论了miR-21在癌症放射治疗中的当前及潜在的未来应用。
