放射治疗中的生物学效应与等效剂量：一种软件解决方案。
Biological effects and equivalent doses in radiotherapy: A software solution.
作者信息
Voyant Cyril, Julian Daniel, Roustit Rudy, Biffi Katia, Lantieri Céline
机构信息
University of Corsica, CNRS UMR SPE 6134, Campus Grimaldi, 20250 Corte, France ; Hospital of Castelluccio, Radiotherapy Unit, BP 85, 20177 Ajaccio, France.
Joseph Fourier University, 38000 Grenoble, France.
出版信息
Rep Pract Oncol Radiother. 2013 Sep 29;19(1):47-55. doi: 10.1016/j.rpor.2013.08.004. eCollection 2014 Jan.
Abstract
BACKGROUND
The limits of TDF (time, dose, and fractionation) and linear quadratic models have been known for a long time. Medical physicists and physicians are required to provide fast and reliable interpretations regarding delivered doses or any future prescriptions relating to treatment changes.
AIM
We, therefore, propose a calculation interface under the GNU license to be used for equivalent doses, biological doses, and normal tumor complication probability (Lyman model).
MATERIALS AND METHODS
THE METHODOLOGY USED DRAWS FROM SEVERAL SOURCES: the linear-quadratic-linear model of Astrahan, the repopulation effects of Dale, and the prediction of multi-fractionated treatments of Thames.
RESULTS AND CONCLUSIONS
The results are obtained from an algorithm that minimizes an ad-hoc cost function, and then compared to an equivalent dose computed using standard calculators in seven French radiotherapy centers.
摘要
背景
长期以来，人们已经知道TDF（时间、剂量和分次）以及线性二次模型的局限性。医学物理学家和医生需要就所给予的剂量或与治疗变化相关的任何未来处方提供快速可靠的解释。
目的
因此，我们提出一个遵循GNU许可的计算界面，用于等效剂量、生物剂量和正常组织并发症概率（莱曼模型）的计算。
材料与方法
所使用的方法来源于多个方面：阿斯特拉罕的线性 - 二次 - 线性模型、戴尔的再增殖效应以及泰晤士对多分次治疗的预测。
结果与结论
结果来自一个使特设成本函数最小化的算法，然后与法国七个放疗中心使用标准计算器计算出的等效剂量进行比较。
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