Metabolic Diseases Institute, University of Cincinnati, United States.
Physiol Behav. 2011 Nov 30;105(1):120-3. doi: 10.1016/j.physbeh.2011.05.026. Epub 2011 Jun 12.
Bariatric surgery is the most efficacious procedure for eliciting weight loss in humans, and many patients undergoing the procedure experience significant lessening of their symptoms of type-2 diabetes in addition to losing weight. We have adapted two bariatric surgical procedures commonly employed in humans to a rat model to begin to understand the mechanisms underlying the improvements in energy homeostasis. Young adult male rats received either roux-en-Y gastric bypass (RYGB) or vertical sleeve gastrectomy (VSG) and were assessed for body weight, food intake and parameters of glucose homeostasis over a 28-week period. Control rats received either a sham surgical procedure or else were unoperated. RYGB and VSG had comparable beneficial effects relative to controls. They ate less food and lost more weight, and they both had improved glucose parameters. The most intriguing aspect of the findings is that the two surgical procedures had such similar effects in spite of quite different rearrangements of the gastrointestinal system.
减重手术是在人类中最有效的减肥方法，许多接受该手术的患者除了体重减轻外，还经历了 2 型糖尿病症状的显著减轻。我们已经将两种常见的人类减重手术方法改编为大鼠模型，以开始了解能量平衡改善的机制。年轻成年雄性大鼠接受 Roux-en-Y 胃旁路术（RYGB）或垂直袖状胃切除术（VSG），并在 28 周的时间内评估体重、食物摄入量和葡萄糖稳态参数。对照大鼠接受假手术或未手术。RYGB 和 VSG 与对照组相比具有相似的有益效果。它们吃得更少，体重减轻更多，并且葡萄糖参数都得到了改善。研究结果最有趣的方面是，尽管胃肠道系统的排列方式非常不同，但两种手术方法具有如此相似的效果。
