Laboratório de Genética, Instituto Butantan, São Paulo, SP, CEP 05503-900, Brazil.
Res Vet Sci. 2012 Aug;93(1):494-7. doi: 10.1016/j.rvsc.2011.05.019. Epub 2011 Jul 2.
Equine herpesvirus type 1 (EHV-1) is associated with abortions, respiratory distress, and neurological disturbances in horses. The ORF37 of EHV-1 encodes a protein homolog to UL24 gene product of human herpesvirus that has been associated with neurovirulence. In the present work, ORF37 PCR fragments derived from two Brazilian EHV-1 isolates, a German isolate and an American reference strain were sequenced and characterized by molecular phylogenetic analysis. This genomic region is highly conserved an allowed to infer genetic distances between EHV-1 strains and other animal herpesvirus.
马疱疹病毒 1 型（EHV-1）与马的流产、呼吸窘迫和神经紊乱有关。EHV-1 的 ORF37 编码与人类疱疹病毒 UL24 基因产物同源的蛋白质，该基因产物与神经毒力有关。在本工作中，对来自两个巴西 EHV-1 分离株、一个德国分离株和一个美国参考株的 ORF37 PCR 片段进行了测序，并通过分子系统发生分析进行了特征描述。该基因组区域高度保守，允许推断 EHV-1 株与其他动物疱疹病毒之间的遗传距离。
