Department of Surgery and Cancer, Imperial College London, London, UK.
Trends Microbiol. 2011 Jul;19(7):349-59. doi: 10.1016/j.tim.2011.05.006. Epub 2011 Jun 22.
There is growing awareness of the importance of the gut microbiome in health and disease, and recognition that the microbe to host metabolic signalling is crucial to understanding the mechanistic basis of their interaction. This opens new avenues of research for advancing knowledge on the aetiopathologic consequences of dysbiosis with potential for identifying novel microbially-related drug targets. Advances in both sequencing technologies and metabolic profiling platforms, coupled with mathematical integration approaches, herald a new era in characterizing the role of the microbiome in metabolic signalling within the host and have far reaching implications in promoting health in both the developed and developing world.
人们越来越意识到肠道微生物组在健康和疾病中的重要性，并且认识到微生物与宿主之间的代谢信号传递对于理解它们相互作用的机制基础至关重要。这为研究微生物失调的病理后果开辟了新的途径，有可能确定新的与微生物相关的药物靶点。测序技术和代谢谱分析平台的进步，加上数学整合方法，预示着在宿主中描述微生物组在代谢信号传递中的作用的新时代的到来，这对促进发达国家和发展中国家的健康都有着深远的影响。
