信使核糖核酸印记：基因表达调控的额外层面。
mRNA imprinting: Additional level in the regulation of gene expression.
作者信息
Choder Mordechai
机构信息
Department of Molecular Microbiology; Rappaport Faculty of Medicine; Technion-Israel Institute of Technology; Haifa, Israel.
出版信息
Cell Logist. 2011 Jan;1(1):37-40. doi: 10.4161/cl.1.1.14465.
Abstract
Following its synthesis in the nucleus, mRNA undergoes various stages that are critical for the proper synthesis, localization and possibly functionality of its encoded protein. Recently, we have shown that two RNA polymerase II (Pol II) subunits, Rpb4p and Rpb7p, associate with the nascent transcript co-transcriptionally. This "mRNA imprinting" lasts throughout the mRNA lifetime and is required for proper regulation of all major stages that the mRNA undergoes. Other possible cases of co-transcriptional imprinting are discussed. Since mRNAs can be transported from the synthesizing cell to other cells, we propose that mRNA imprinting can also affect the phenotype of the recipient cells. This can be viewed as "mRNA-based epigenetics."
摘要
在细胞核中合成后，信使核糖核酸（mRNA）会经历多个对其编码蛋白质的正确合成、定位以及可能的功能至关重要的阶段。最近，我们发现RNA聚合酶II（Pol II）的两个亚基Rpb4p和Rpb7p在转录过程中与新生转录本相关联。这种“mRNA印记”在mRNA的整个生命周期中持续存在，并且是mRNA经历的所有主要阶段进行适当调控所必需的。文中还讨论了其他可能的转录共印记情况。由于mRNA可以从合成细胞转运到其他细胞，我们提出mRNA印记也可能影响受体细胞的表型。这可以被视为“基于mRNA的表观遗传学”。
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