Robinson Douglas N
Departments of Cell Biology; Pharmacology and Molecular Sciences; Johns Hopkins University School of Medicine; Department of Chemical and Biomolecular Engineering; Johns Hopkins University; Baltimore, MD USA.
Small GTPases. 2010 Nov;1(3):165-169. doi: 10.4161/sgtp.1.3.14432.
One of the goals of understanding cytokinesis is to uncover the molecular regulation of the cellular mechanical properties that drive cell shape change. Such regulatory pathways are likely to be used at multiple stages of a cell's life, but are highly featured during cell division. Recently, we demonstrated that 14-3-3 (encoded by a single gene in the social amoeba Dictyostelium discoideum) serves to integrate key cytoskeletal components-microtubules, Rac and myosin II-to control cell mechanics and cytokinesis. As 14-3-3 proteins are frequently altered in a variety of human tumors, we extend these observations to suggest possible additional roles for how 14-3-3 proteins may contribute to tumorigenesis.
理解胞质分裂的目标之一是揭示驱动细胞形状变化的细胞力学特性的分子调控机制。此类调控途径可能在细胞生命的多个阶段发挥作用，但在细胞分裂过程中表现尤为突出。最近，我们证明了14-3-3蛋白（由黏菌盘基网柄菌中的单个基因编码）可整合关键的细胞骨架成分——微管、Rac和肌球蛋白II——以控制细胞力学和胞质分裂。由于14-3-3蛋白在多种人类肿瘤中经常发生改变，我们进一步拓展这些观察结果，以探讨14-3-3蛋白可能在肿瘤发生过程中发挥的其他潜在作用。
