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本文引用的文献

1
Prevention of varicella: recommendations of the Advisory Committee on Immunization Practices (ACIP).水痘预防：免疫实践咨询委员会（ACIP）的建议
MMWR Recomm Rep. 2007 Jun 22;56(RR-4):1-40.
2
A novel mutation of varicella-zoster virus associated to fatal hepatitis.一种与致命性肝炎相关的水痘-带状疱疹病毒新突变。
J Clin Virol. 2006 Sep;37(1):72-4. doi: 10.1016/j.jcv.2006.06.004. Epub 2006 Jul 28.
3
Fulminating varicella despite prophylactic immune globulin and intravenous acyclovir in a renal transplant recipient: should renal patients be vaccinated against VZV before transplantation?肾移植受者尽管接受了预防性免疫球蛋白和静脉注射阿昔洛韦治疗仍发生暴发性水痘：肾病患者在移植前是否应接种水痘带状疱疹病毒疫苗？
Clin Transplant. 2006 Jan-Feb;20(1):136-8. doi: 10.1111/j.1399-0012.2005.00435.x.
4
Fatal varicella infection in a girl with systemic lupus erythematosus after oral acyclovir prophylaxis.口服阿昔洛韦预防后，一名系统性红斑狼疮女孩发生致命性水痘感染。
Eur J Pediatr. 2006 Apr;165(4):280-1. doi: 10.1007/s00431-005-0066-z. Epub 2006 Jan 13.
5
A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults.一种预防老年人带状疱疹及带状疱疹后神经痛的疫苗。
N Engl J Med. 2005 Jun 2;352(22):2271-84. doi: 10.1056/NEJMoa051016.
6
Decline in mortality due to varicella after implementation of varicella vaccination in the United States.美国实施水痘疫苗接种后水痘所致死亡率的下降
N Engl J Med. 2005 Feb 3;352(5):450-8. doi: 10.1056/NEJMoa042271.
7
Varicella-zoster virus: atypical presentations and unusual complications.水痘-带状疱疹病毒：非典型表现及罕见并发症
J Infect Dis. 2002 Oct 15;186 Suppl 1:S91-8. doi: 10.1086/342963.
8
Varicella-zoster virus gE escape mutant VZV-MSP exhibits an accelerated cell-to-cell spread phenotype in both infected cell cultures and SCID-hu mice.水痘带状疱疹病毒gE逃逸突变体VZV-MSP在感染的细胞培养物和SCID-hu小鼠中均表现出加速的细胞间传播表型。
Virology. 2000 Sep 30;275(2):306-17. doi: 10.1006/viro.2000.0507.
9
Acute abdomen without cutaneous signs of varicella zoster virus infection as a late complication of allogeneic bone marrow transplantation: importance of empiric therapy with acyclovir.急性腹痛作为异基因骨髓移植的晚期并发症，无水痘带状疱疹病毒感染的皮肤体征：阿昔洛韦经验性治疗的重要性。
Bone Marrow Transplant. 2000 May;25(9):1003-5. doi: 10.1038/sj.bmt.1702340.
10
Antigenic variation of varicella zoster virus Fc receptor gE: loss of a major B cell epitope in the ectodomain.水痘带状疱疹病毒Fc受体gE的抗原变异：胞外结构域中一个主要B细胞表位的缺失
Virology. 1998 Sep 15;249(1):21-31. doi: 10.1006/viro.1998.9313.

免疫功能低下者接种水痘疫苗的理由。

A case for varicella vaccination in the immunosuppressed.

作者信息

Holmes Michael Vaclav, Atabani Sowsan F, Khan Nasser, Steiner Kate, Haque Tanzina, Slapak Gabrielle

机构信息

Royal Free Hospital NHS Trust, Pond Street, London NW3 2XA, UK.

出版信息

BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.07.2008.0461. Epub 2009 Mar 17.

DOI:10.1136/bcr.07.2008.0461
PMID:21686799
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3029559/
Abstract

A middle-aged man with long-standing Crohn disease maintained in remission on low-dose immunosuppression presented with abdominal pain. Over the following few days he developed a vesicular rash, became dyspnoeic, confused and had two seizures. Despite high-dose intravenous aciclovir, he died. Disseminated varicella zoster virus, the cause of his death, could potentially have been prevented had he received varicella vaccination at an earlier stage.

摘要

一名长期患有克罗恩病的中年男子，通过低剂量免疫抑制治疗维持病情缓解，现出现腹痛症状。在接下来的几天里，他出现了水疱性皮疹，呼吸困难，意识模糊，并发生了两次癫痫发作。尽管接受了大剂量静脉注射阿昔洛韦治疗，他还是去世了。他的死因是播散性水痘带状疱疹病毒，如果他在早期接种水痘疫苗，这种情况可能会得到预防。