Laupacis Andreas, Slutsky Arthur S
Open Med. 2010;4(4):e197-9. Epub 2010 Dec 7.
The Canadian Institutes of Health Research and the Multiple Sclerosis (MS) Society of Canada recently convened an Invitational Panel to consider the scientific evidence linking chronic cerebrospinal venous insufficiency (CCSVI) and MS. The panel supported studies to determine whether CCSVI causes MS, but felt that there is currently so much uncertainty about the relationship between CCSVI and MS that a clinical trial is not indicated at this time. This commentary argues that the decision about whether a clinical trial is warranted must be informed by science, but should be addressed from a broader societal perspective. We suggest that members of the public should be more actively involved in scientifically based, but patient-relevant and emotionally charged issues considered by organizations that fund health research.
加拿大卫生研究院和加拿大多发性硬化症协会最近召集了一个特邀专家小组，以审议有关慢性脑脊髓静脉功能不全（CCSVI）与多发性硬化症（MS）之间联系的科学证据。该小组支持开展研究以确定CCSVI是否会导致MS，但认为目前CCSVI与MS之间的关系存在太多不确定性，因此现阶段不适合进行临床试验。本评论认为，关于是否有必要进行临床试验的决定必须以科学为依据，但应从更广泛的社会角度来探讨。我们建议公众应更积极地参与由资助健康研究的组织所考虑的、基于科学但与患者相关且充满情感的问题。
