番石榴叶甲醇提取物的体外抗菌活性
In vitro antimicrobial activity of methanolic leaf extract of Psidium guajava L.
作者信息
Dhiman Anju, Nanda Arun, Ahmad Sayeed, Narasimhan B
机构信息
Department of Pharmaceutical Sciences, M.D. University, Rohtak, Haryana, India.
出版信息
J Pharm Bioallied Sci. 2011 Apr;3(2):226-9. doi: 10.4103/0975-7406.80776.
Abstract
AIM
This study was designed to examine the chemical composition and in vitro antimicrobial potential of methanolic extract of Psidium guajava Linn (Myrtaceae).
MATERIALS AND METHODS
The inhibitory effect of methanolic extract of P. guajava was tested against three bacterial and two fungal strains by using the paper disc diffusion method.
RESULTS
The methanolic extract exhibited antibacterial activity against E. coli with minimum inhibitory concentration, 0.78 μg/ml, minimum bactericidal concentration of 50 μg/ml, and appreciable antifungal activity with minimum inhibitory concentration of 12.5 μg/ml. Preliminary phytochemical analysis of methanolic extract revealed the presence of antimicrobial compounds such as flavonoids, steroids, and tannins, which may contribute for the antimicrobial action of P. guajava.
CONCLUSION
The extract was found to be bacteriostatic and fungistatic in action.
摘要
目的
本研究旨在检测番石榴（桃金娘科）甲醇提取物的化学成分及体外抗菌潜力。
材料与方法
采用纸片扩散法检测番石榴甲醇提取物对三种细菌菌株和两种真菌菌株的抑制作用。
结果
番石榴甲醇提取物对大肠杆菌表现出抗菌活性，最低抑菌浓度为0.78μg/ml，最低杀菌浓度为50μg/ml，对真菌也有显著的抗真菌活性，最低抑菌浓度为12.5μg/ml。对甲醇提取物的初步植物化学分析表明，其中存在黄酮类、甾体类和单宁等抗菌化合物，这些可能是番石榴具有抗菌作用的原因。
结论
该提取物具有抑菌和抑真菌作用。
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