Alves Naira Moura, Nunes Paulo Humberto Moreira, Mendes Garcez Anderson, Lima de Freitas Manoela Carine, Oliveira Irisdalva Sousa, da Silva Francilene Vieira, Fernandes Hélio de Barros, de Sousa Damião Pergentino, Oliveira Rita de Cássia Meneses, Arcanjo Daniel Dias Rufino, Martins Maria do Carmo de Carvalho E
Medicinal Plants Research Center, Federal University of Piauí, Teresina, PI, Brazil.
Department of Biophysics and Physiology, Federal University of Piauí, Teresina, PI, Brazil.
Evid Based Complement Alternat Med. 2023 Apr 7;2023:9192494. doi: 10.1155/2023/9192494. eCollection 2023.
Menthofuran is a monoterpene present in various essential oils derived from species from genus, and in Brazil, those species are widely used in treating gastrointestinal and respiratory disorders. Considering the wide pharmacological potential of monoterpenes, including their antioxidant activity, this study aimed to evaluate menthofuran-gastroprotective activity, as well as the involvement of antioxidant mechanisms in this effect. The acute toxicity was evaluated according to the fixed dose method. The antiulcerogenic activity was investigated by using experimental models of gastric ulcers induced by ethanol, indomethacin, and ischemia/reperfusion in rats. The antisecretory gastric activity, the catalase activity, and the gastric wall mucus were determined in pylorus ligated rats. Gastric wall nonprotein sulfhydryl (NPSH) group content, myeloperoxidase (MPO) activity, and malondialdehyde (MDA) content were evaluated in ethanol-induced the gastric ulcer model. Menthofuran (2 g/kg) presented low acute toxicity and showed gastroprotective activity against ethanol-, indomethacin-, and ischemia/reperfusion-induced ulcers. Moreover, menthofuran presented antisecretory activity, reduced the total acidity, and increased pH of gastric secretion. On the other hand, a decrease in mucus content of gastric wall without alteration of gastric juice volume and catalase activity was observed. Interestingly, menthofuran increased NPSH levels and reduced MDA levels and MPO activity. Gastroprotective effects of menthofuran appear to be mediated, at least in part, by the NOS pathway, endogenous prostaglandins, reduced gastric juice acidity, increased concentration of the NPSH groups, and reduced lipidic peroxidation. These findings support the menthofuran as an effective gastroprotective agent, as well as the marked participation of antioxidant mechanisms in this response.
薄荷呋喃是一种单萜类化合物，存在于多种来自该属植物的精油中，在巴西，这些植物被广泛用于治疗胃肠道和呼吸道疾病。鉴于单萜类化合物具有广泛的药理潜力，包括其抗氧化活性，本研究旨在评估薄荷呋喃的胃保护活性，以及抗氧化机制在该效应中的作用。根据固定剂量法评估急性毒性。通过使用乙醇、吲哚美辛和缺血/再灌注诱导的大鼠胃溃疡实验模型来研究抗溃疡活性。在幽门结扎的大鼠中测定胃抗分泌活性、过氧化氢酶活性和胃壁黏液。在乙醇诱导的胃溃疡模型中评估胃壁非蛋白巯基（NPSH）组含量、髓过氧化物酶（MPO）活性和丙二醛（MDA）含量。薄荷呋喃（2 g/kg）表现出低急性毒性，并对乙醇、吲哚美辛和缺血/再灌注诱导的溃疡具有胃保护活性。此外，薄荷呋喃具有抗分泌活性，降低了总酸度，并提高了胃分泌的pH值。另一方面，观察到胃壁黏液含量减少，而胃液体积和过氧化氢酶活性未改变。有趣的是，薄荷呋喃增加了NPSH水平，降低了MDA水平和MPO活性。薄荷呋喃的胃保护作用似乎至少部分是由一氧化氮合酶（NOS）途径、内源性前列腺素、降低的胃液酸度、增加的NPSH组浓度和减少的脂质过氧化介导的。这些发现支持薄荷呋喃作为一种有效的胃保护剂，以及抗氧化机制在这一反应中的显著参与。
