Misra Himanshu, Soni Manish, Silawat Narendra, Mehta Darshana, Mehta B K, Jain D C
School of Studies in Chemistry and Biochemistry, Vikram University, Ujjain - 456 010, Madhya Pradesh, India.
J Pharm Bioallied Sci. 2011 Apr;3(2):242-8. doi: 10.4103/0975-7406.80779.
To investigate the medicative effects of medium-polar (benzene:acetone, 1:1, v/v) extract of leaves from Stevia rebaudiana (family Asteraceae) on alloxan-induced diabetic rats.
Diabetes was induced in adult albino Wistar rats by intraperitoneal (i.p.) injection of alloxan (180 mg/kg). Medium-polar extract was administered orally at daily dose of 200 and 400 mg/kg body wt. basis for 10 days. The control group received normal saline (0.9%) for the same duration. Glibenclamide was used as positive control reference drug against Stevia extract.
Medium-polar leaf extract of S. rebaudiana (200 and 400 mg/kg) produced a delayed but significant (P < 0.01) decrease in the blood glucose level, without producing condition of hypoglycemia after treatment, together with lesser loss in the body weight as compared with standard positive control drug glibenclamide.
Treatment of diabetes with sulfonylurea drugs (glibenclamide) causes hypoglycemia followed by greater reduction in body weight, which are the most worrisome effects of these drugs. Stevia extract was found to antagonize the necrotic action of alloxan and thus had a re-vitalizing effect on β-cells of pancreas.
研究甜叶菊（菊科）叶的中极性提取物（苯：丙酮，1:1，v/v）对四氧嘧啶诱导的糖尿病大鼠的药用效果。
通过腹腔注射四氧嘧啶（180 mg/kg）诱导成年白化Wistar大鼠患糖尿病。以200和400 mg/kg体重的日剂量口服给予中极性提取物，持续10天。对照组在相同时间段内给予生理盐水（0.9%）。格列本脲用作甜叶菊提取物的阳性对照参考药物。
甜叶菊的中极性叶提取物（200和400 mg/kg）使血糖水平出现延迟但显著（P < 0.01）的下降，治疗后未出现低血糖情况，与标准阳性对照药物格列本脲相比，体重减轻较少。
用磺脲类药物（格列本脲）治疗糖尿病会导致低血糖，随后体重进一步减轻，这是这些药物最令人担忧的副作用。发现甜叶菊提取物可拮抗四氧嘧啶的坏死作用，因此对胰腺β细胞具有恢复活力的作用。
