Zdravkovic Vladimir, Pantovic Suzana, Rosic Gvozden, Tomic-Lucic Aleksandra, Zdravkovic Nemanja, Colic Maja, Obradovic Zdravko, Rosic Mirko
Department of Physiology, Faculty of Medicine, University of Kragujevac, Kragujevac, Serbia.
J Biomed Biotechnol. 2011;2011:315709. doi: 10.1155/2011/315709. Epub 2011 Jun 6.
The aim of this study was to investigate histamine blood concentration in subjects suffering from different types of ischemic heart diseases during the period of eight days. Our results showed that the histamine blood level was associated with different types of ischemic heart diseases. The blood histamine level in all investigated patients was significantly higher when compared to control subjects (44.87 ± 1.09 ng mL(-1)), indicating the increase of histamine release in patients suffering from coronary diseases. In patients suffering from ACS-UA and ACS-STEMI, the second day peak of histamine level occurs (90.85 ± 6.34 ng mL(-1) and 121.7 ± 6.34 ng mL(-1), resp.) probably as the reperfusion event. Furthermore, our data suggest that histamine can be additional parameter of myocardial ischemia along with cardiac specific enzymes and may prove to be an excellent single prognostic marker for multitude of ischemic heart diseases.
本研究的目的是调查不同类型缺血性心脏病患者在八天期间的组胺血浓度。我们的结果表明，组胺血水平与不同类型的缺血性心脏病有关。与对照组受试者（44.87±1.09 ng mL⁻¹）相比，所有受调查患者的血组胺水平均显著更高，表明冠心病患者组胺释放增加。在患有不稳定型心绞痛（ACS-UA）和ST段抬高型心肌梗死（ACS-STEMI）的患者中，组胺水平的第二天峰值出现（分别为90.85±6.34 ng mL⁻¹和121.7±6.34 ng mL⁻¹），这可能是再灌注事件所致。此外，我们的数据表明，组胺可能是除心脏特异性酶之外的心肌缺血的附加参数，并且可能被证明是多种缺血性心脏病的优秀单一预后标志物。
