Dai Shipan, Mohapatra Nrusingh P, Schlesinger Larry S, Gunn John S
Center for Microbial Interface Biology, The Ohio State University Columbus, OH, USA.
Front Microbiol. 2011 Jan 6;1:144. doi: 10.3389/fmicb.2010.00144. eCollection 2010.
Francisella tularensis is one of the most virulent bacteria known and a Centers for Disease Control and Prevention Category A select agent. It is able to infect a variety of animals and insects and can persist in the environment, thus Francisella spp. must be able to survive in diverse environmental niches. However, F. tularensis has a surprising dearth of sensory and regulatory factors. Recent advancements in the field have identified new functions of encoded transcription factors and greatly expanded our understanding of virulence gene regulation. Here we review the current knowledge of environmental adaptation by F. tularensis, its transcriptional regulators and their relationship to animal virulence.
土拉弗朗西斯菌是已知毒性最强的细菌之一，也是美国疾病控制与预防中心指定的A类生物制剂。它能够感染多种动物和昆虫，并能在环境中持续存在，因此弗朗西斯菌属必须能够在不同的环境生态位中生存。然而，土拉弗朗西斯菌的感觉和调节因子出奇地匮乏。该领域最近的进展已经确定了编码转录因子的新功能，并极大地扩展了我们对毒力基因调控的理解。在这里，我们综述了目前关于土拉弗朗西斯菌环境适应性、其转录调节因子及其与动物毒力关系的知识。
