Department of Thoracic Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, China.
Dis Esophagus. 2012 Jan;25(1):67-71. doi: 10.1111/j.1442-2050.2011.01217.x. Epub 2011 Jun 20.
The prognostic effect of p21(WAF1) expression on esophageal squamous cell carcinoma patients is controversial. Further clarifying the effect of this protein is beneficial for optimizing the patient outcomes. In the current study, we investigated the expression of p21(WAF1) protein in 189 specimens of stage III ESCC by immunohistochemistry. As shown by the Kaplan-Meier curve, the overall survival rate of the positive-expression group was significantly higher than that of the negative-expression group (P < 0.05). No significant correlation was observed between p21(WAF1) expression and clinicopathological parameters in terms of gender, age, tumor location, tumor grade, pathological stage, and number of regional lymph node metastases (P > 0.05). We concluded that p21(WAF1) played an intricate role in the tumorigenesis and development of ESCC. p21(WAF1) could serve as a positive prognostic predictor for stage III ESCC patients.
p21(WAF1) 表达对食管鳞癌患者的预后影响存在争议。进一步阐明该蛋白的作用有利于优化患者的预后。本研究采用免疫组织化学方法检测了 189 例 III 期 ESCC 标本中 p21(WAF1)蛋白的表达。Kaplan-Meier 曲线显示，p21(WAF1)阳性表达组的总生存率明显高于阴性表达组（P<0.05）。p21(WAF1)表达与性别、年龄、肿瘤部位、肿瘤分级、病理分期和区域淋巴结转移数等临床病理参数之间无显著相关性（P>0.05）。综上，p21(WAF1)在 ESCC 的发生发展中起复杂作用，p21(WAF1)可能是 III 期 ESCC 的一个阳性预后预测因子。
