Department of Dermatology and Medicine (Oncology), Duke University Medical Center, Durham, North Carolina 27110, USA.
Dermatol Ther. 2011 May-Jun;24(3):311-9. doi: 10.1111/j.1529-8019.2011.01415.x.
The reported efficacy of various treatments for alopecia is difficult to compare based on a general lack of consideration in case reports/series and clinical trials of the spontaneous regrowth or baseline prognostic factors seen in alopecia areata and a general lack of quantification of hair growth. This report will give both the investigator and clinician guidelines for clinical trial design that will take into account variables known to effect efficacy results such as baseline severity, pattern, and duration of hair loss, age of the subject, and concomitant conditions that may impact on potential regrowth. Reliable methods of assessment of efficacy and response criteria that will enable direct comparison of results between agents will also be discussed.
由于斑秃病例报告/系列和临床试验普遍缺乏对自发性再生或斑秃基线预后因素的考虑，以及对毛发生长的普遍缺乏量化，因此各种治疗斑秃的疗效报道难以进行比较。本报告将为研究者和临床医生提供临床试验设计指南，这些指南将考虑到已知会影响疗效结果的变量，如脱发的基线严重程度、模式和持续时间、受试者的年龄以及可能影响潜在再生的伴随疾病。还将讨论评估疗效的可靠方法和反应标准，这些方法和标准将使药物之间的结果能够直接进行比较。
