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回顾性研究疾病进展对 HER-2 阴性转移性乳腺癌患者报告结局的影响。

Retrospective study of the effect of disease progression on patient reported outcomes in HER-2 negative metastatic breast cancer patients.

机构信息

ACORN Research, LLC, 6555 Quince, Suite 400, Memphis, TN 38119, USA.

出版信息

Health Qual Life Outcomes. 2011 Jun 20;9:46. doi: 10.1186/1477-7525-9-46.

DOI:10.1186/1477-7525-9-46
PMID:21689425
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3142199/
Abstract

BACKGROUND

This retrospective study evaluated the impact of disease progression and of specific sites of metastasis on patient reported outcomes (PROs) that assess symptom burden and health related quality of life (HRQoL) in women with metastatic breast cancer (mBC).

METHODS

HER-2 negative mBC patients (n = 102) were enrolled from 7 U.S. community oncology practices. Demographic, disease and treatment characteristics were abstracted from electronic medical records and linked to archived Patient Care Monitor (PCM) assessments. The PCM is a self-report measure of symptom burden and HRQoL administered as part of routine care in participating practices. Linear mixed models were used to examine change in PCM scores over time.

RESULTS

Mean age was 57 years, with 72% of patients Caucasian, and 25% African American. Median time from mBC diagnosis to first disease progression was 8.8 months. Metastasis to bone (60%), lung (28%) and liver (26%) predominated at initial metastatic diagnosis. Results showed that PCM items assessing fatigue, physical pain and trouble sleeping were sensitive to either general effects of disease progression or to effects associated with specific sites of metastasis. Progression of disease was also associated with modest but significant worsening of General Physical Symptoms, Treatment Side Effects, Acute Distress and Impaired Performance index scores. In addition, there were marked detrimental effects of liver metastasis on Treatment Side Effects, and of brain metastasis on Acute Distress.

CONCLUSIONS

Disease progression has a detrimental impact on cancer-related symptoms. Delaying disease progression may have a positive impact on patients' HRQoL.

摘要

背景

本回顾性研究评估了疾病进展和特定转移部位对转移性乳腺癌（mBC）女性患者报告结局（PROs）的影响，这些 PROs 评估了症状负担和健康相关生活质量（HRQoL）。

方法

从 7 家美国社区肿瘤学实践中招募了 HER-2 阴性 mBC 患者（n=102）。从电子病历中提取人口统计学、疾病和治疗特征，并与存档的患者护理监测（PCM）评估结果相关联。PCM 是一种自我报告的症状负担和 HRQoL 测量工具，作为参与实践中常规护理的一部分进行管理。使用线性混合模型来检查 PCM 评分随时间的变化。

结果

平均年龄为 57 岁，72%的患者为白种人，25%为非裔美国人。从 mBC 诊断到首次疾病进展的中位时间为 8.8 个月。初始转移性诊断时，骨转移（60%）、肺转移（28%）和肝转移（26%）最为常见。结果表明，评估疲劳、身体疼痛和睡眠困难的 PCM 项目对疾病进展的一般影响或与特定转移部位相关的影响敏感。疾病进展还与一般躯体症状、治疗副作用、急性痛苦和受损功能指数评分的适度但显著恶化相关。此外，肝转移对治疗副作用，脑转移对急性痛苦有明显的不利影响。

结论

疾病进展对癌症相关症状有不利影响。延迟疾病进展可能对患者的 HRQoL 产生积极影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1904/3142199/2cebbc4def50/1477-7525-9-46-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1904/3142199/219329404e16/1477-7525-9-46-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1904/3142199/33b166d6f188/1477-7525-9-46-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1904/3142199/2cebbc4def50/1477-7525-9-46-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1904/3142199/219329404e16/1477-7525-9-46-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1904/3142199/33b166d6f188/1477-7525-9-46-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1904/3142199/2cebbc4def50/1477-7525-9-46-3.jpg

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