胰岛素抵抗及其他代谢危险因素在肝细胞癌发病机制中的作用。
Insulin resistance and other metabolic risk factors in the pathogenesis of hepatocellular carcinoma.
机构信息
Center for Liver Disease, Virginia Mason Medical Center, Digestive Disease Institute, 1100 Ninth Avenue, PO Box 900, Seattle, WA 98111, USA.
出版信息
Clin Liver Dis. 2011 May;15(2):281-96, vii-x. doi: 10.1016/j.cld.2011.03.007.
Coinciding with the increased incidence of hepatocellular carcinoma (HCC), there has been a significant increase in the global incidence of obesity and diabetes mellitus (DM), the two major risk factors for nonalcoholic steatohepatitis (NASH). There are many causes of HCC, and nonalcoholic fatty liver disease/NASH is now emerging as a leading risk factor owing to the epidemic of obesity and type 2 DM. The mechanisms leading to HCC in obesity and type 2 DM likely involve interactions between several signaling pathways, including oxidative stress, inflammation, oncogenes, adiponectins, and insulin resistance associated with visceral adiposity and diabetes.
随着肝细胞癌 (HCC) 的发病率增加，肥胖症和糖尿病 (DM) 的全球发病率也显著上升，这两种疾病是非酒精性脂肪性肝炎 (NASH) 的两个主要危险因素。HCC 的病因很多，由于肥胖症和 2 型糖尿病的流行，非酒精性脂肪性肝病/NASH 现已成为主要的危险因素。肥胖症和 2 型糖尿病导致 HCC 的机制可能涉及包括氧化应激、炎症、癌基因、脂联素以及与内脏肥胖和糖尿病相关的胰岛素抵抗等几种信号通路的相互作用。
Zotero 插件